{"id":"W4229615272","doi":"10.1002/ange.201506312","title":"Binding‐Induced DNA Nanomachines Triggered by Proteins and Nucleic Acids","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Oligonucleotide; DNA; Nucleic acid; Biophysics; Aptamer; Chemistry; DNA nanotechnology; Ligand (biochemistry); Nanotechnology; Combinatorial chemistry; Biochemistry; Biology; Materials science; Molecular biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853237,0.0002047822,0.0002067924,0.0000422289,0.00007811548,0.00003762263,0.0001251632,0.0001982715,0.000001916769],"category_scores_gemma":[0.0001020312,0.0001689063,0.00007251553,0.0001260512,0.00009056496,0.000007319838,0.0001010176,0.0000837998,0.000003482155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000018166,"about_ca_system_score_gemma":0.00004105882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002050103,"about_ca_topic_score_gemma":0.00001306962,"domain_scores_codex":[0.999043,0.00002710612,0.0001751262,0.0003888162,0.0001304862,0.0002354633],"domain_scores_gemma":[0.9993722,0.000005428122,0.00009043582,0.0002899577,0.00008368089,0.000158225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005052498,0.00003976948,0.0004634931,0.000008305994,0.00004656747,0.000002797689,0.00003261955,2.766293e-8,0.9907788,0.000003107357,0.007536727,0.001037243],"study_design_scores_gemma":[0.0004968151,0.0002200825,0.00003993621,0.00001294022,0.0000354129,0.00001993157,0.000067626,0.000001903825,0.9669504,0.00006887873,0.03184476,0.000241322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973344,0.0007461577,0.00007131283,0.0002461765,0.0000385155,0.0001551304,0.00003760544,0.00007050633,0.001300224],"genre_scores_gemma":[0.9959651,0.0001480101,0.001642151,0.0001878084,0.0001571431,0.00001549886,0.0002310007,0.00002710278,0.001626224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02430804,"threshold_uncertainty_score":0.6887798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794256805268303,"score_gpt":0.2657457098297072,"score_spread":0.2478031417770242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}