{"id":"W4229735891","doi":"10.1158/1538-7445.am2019-3088","title":"Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"KRAS; Farnesyltransferase; Cancer research; Pancreatic cancer; Cancer; Prenylation; Carcinogenesis; PI3K/AKT/mTOR pathway; Protein kinase B; EGFR inhibitors; Biology; Medicine; Apoptosis; Epidermal growth factor receptor; Colorectal cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004893797,0.0004606097,0.0008461752,0.0004231953,0.0002695231,0.00008792316,0.00027803,0.0002008222,0.0043351],"category_scores_gemma":[0.0001247732,0.0003952335,0.0002369682,0.000804354,0.0004614687,0.000357951,0.00009619682,0.001275816,0.000617066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008340911,"about_ca_system_score_gemma":0.001058831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000621546,"about_ca_topic_score_gemma":0.00008992602,"domain_scores_codex":[0.9950482,0.0002003653,0.0006505135,0.0009746266,0.001710815,0.001415499],"domain_scores_gemma":[0.9973052,0.000384845,0.0001084535,0.0009176506,0.0006707142,0.0006132075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002892687,0.0002833414,0.005034218,0.0005403906,0.0002273776,0.0004677599,0.003057181,0.0002048853,0.9514222,0.00008420757,0.0002534569,0.03553228],"study_design_scores_gemma":[0.01239565,0.002056245,0.03925182,0.00286021,0.0001192707,0.0002906142,0.004170972,0.0001942112,0.9027935,0.0004344855,0.03430641,0.001126572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912524,0.002437222,0.00003585881,0.001872207,0.0004930161,0.002383019,0.0001567694,0.0001904285,0.001179116],"genre_scores_gemma":[0.9968466,0.000362134,0.0001795052,0.0004550197,0.0006993566,0.0006592327,0.00005610647,0.0001630986,0.0005789574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04862868,"threshold_uncertainty_score":0.99985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03989486226974744,"score_gpt":0.351024661300706,"score_spread":0.3111297990309586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}