{"id":"W4229791719","doi":"10.1080/10408440600977677","title":"IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans","year":2006,"lang":"en","type":"article","venue":"Critical Reviews in Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":460,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"World Health Organization","keywords":"Relevance (law); Identification (biology); Action (physics); Cancer; Key (lock); Harmonization; Medicine; Computer science; Risk analysis (engineering); Bioinformatics; Psychology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06453565,0.00359939,0.003200484,0.01677405,0.002448992,0.006709899,0.006769497,0.006541263,0.008250358],"category_scores_gemma":[0.04804273,0.001293,0.007376994,0.006974553,0.01182649,0.00412963,0.005675333,0.00840883,0.002335943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01005934,"about_ca_system_score_gemma":0.01713333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01090238,"about_ca_topic_score_gemma":0.005692691,"domain_scores_codex":[0.9451863,0.03333397,0.003376019,0.002681724,0.01430269,0.001119238],"domain_scores_gemma":[0.9651703,0.01951193,0.002891129,0.003740881,0.007896203,0.00078956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003256632,0.00003149827,0.0002759629,0.0007918634,0.0001420183,0.000142219,0.0002181658,0.01030081,0.0003060743,0.9602497,0.01214343,0.01536577],"study_design_scores_gemma":[0.00003160673,0.0001481514,0.0007101285,0.0006666359,0.0001594181,0.0002571185,0.0001504378,0.005935998,0.0004667385,0.8550847,0.136323,0.00006615816],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.001613012,0.01176095,0.8907871,0.01969153,0.001662893,0.001600205,0.00334643,0.0006002116,0.06893758],"genre_scores_gemma":[0.08989487,0.01506383,0.8634551,0.007841585,0.002707076,0.008073908,0.002903095,0.0002296529,0.009830889],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.06453565,"threshold_uncertainty_score":0.3413012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04913151203669107,"score_gpt":0.4331451841007292,"score_spread":0.3840136720640381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}