{"id":"W4229798922","doi":"10.1200/jco.2019.37.15_suppl.tps2072","title":"EORTC 1709/CCTG CE.8: A phase III trial of marizomib in combination with standard temozolomide-based radiochemotherapy versus standard temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Queen's University","funders":"","keywords":"Temozolomide; Medicine; Oncology; Internal medicine; Dacarbazine; Radiation therapy; Population; Phases of clinical research; Clinical trial; Quality of life (healthcare); Chemotherapy; Concomitant; Randomized controlled trial; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002406304,0.002159703,0.001934447,0.000791541,0.0004243606,0.0009053128,0.001471759,0.001838915,0.006196277],"category_scores_gemma":[0.001624723,0.0006739878,0.001464288,0.0006467144,0.001162352,0.0008433818,0.0003997356,0.003695997,0.001225674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001846205,"about_ca_system_score_gemma":0.002863386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004494819,"about_ca_topic_score_gemma":0.01403638,"domain_scores_codex":[0.9993805,0.0003538977,0.00002506615,0.00007042269,0.00005838964,0.0001117476],"domain_scores_gemma":[0.9992363,0.0001224395,0.0001744011,0.00004133221,0.00005311632,0.0003724212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9204704,0.0200907,0.001572935,0.001032116,0.0007054303,0.0001132651,0.00008410249,0.001109944,0.008734723,0.000426057,0.007612475,0.03804789],"study_design_scores_gemma":[0.9096966,0.08468818,0.002355969,0.00004711024,0.0003048632,0.00007421646,0.00002155573,0.0006881407,0.0005636915,0.0001586731,0.001382249,0.0000187637],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676028,0.00644963,0.0007663413,0.002184178,0.0009497735,0.01177077,0.00379107,0.0003192484,0.00616607],"genre_scores_gemma":[0.9627408,0.004787361,0.00330998,0.003157612,0.0006243365,0.0113024,0.005963848,0.00009913309,0.008014576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006196277,"threshold_uncertainty_score":0.02072865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655852670944405,"score_gpt":0.3693833988394558,"score_spread":0.3428248721300117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}