{"id":"W4230033845","doi":"10.1200/jco.2009.27.15_suppl.e14519","title":"Phase I/II trial of oncolytic reovirus (Reolysin) in combination with carboplatin/paclitaxel in patients (pts) with advanced solid cancers","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Oncolytic virus; Carboplatin; Tolerability; Gastroenterology; Nausea; Clinical endpoint; Chills; Cancer; Oncology; Pharmacology; Chemotherapy; Adverse effect; Clinical trial; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008702825,0.001299999,0.001422489,0.0003323155,0.0003396063,0.000819278,0.000731723,0.000899689,0.002571714],"category_scores_gemma":[0.0006004242,0.0004850182,0.0006454954,0.0003611918,0.0008717477,0.0005889095,0.0003179887,0.002484058,0.0005156877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008745714,"about_ca_system_score_gemma":0.001035012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069985,"about_ca_topic_score_gemma":0.002466704,"domain_scores_codex":[0.9997334,0.000134575,0.00001289771,0.00004700411,0.00002286526,0.0000493146],"domain_scores_gemma":[0.9996124,0.00006741073,0.00006845584,0.00003762083,0.00001900501,0.0001952764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7079348,0.1100363,0.008525217,0.0006730108,0.00089516,0.0004864788,0.0004334672,0.003857054,0.08926032,0.0004401881,0.00333106,0.07412699],"study_design_scores_gemma":[0.4125613,0.5615616,0.01244394,0.0000300361,0.0002554712,0.0003378439,0.00009972058,0.00166862,0.008303216,0.0001768735,0.002537943,0.00002350155],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958591,0.0005896533,0.0003079,0.000201595,0.00006276444,0.001525352,0.0003431001,0.00004130483,0.001069137],"genre_scores_gemma":[0.9937724,0.0006512015,0.00101545,0.0003057299,0.00009174725,0.001239524,0.0009391719,0.00001670905,0.001968117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002571714,"threshold_uncertainty_score":0.008603215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04682585551014987,"score_gpt":0.4531171503903668,"score_spread":0.406291294880217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}