{"id":"W4230040793","doi":"10.1016/j.bpj.2017.11.716","title":"Functional Validation of Heteromeric Kainate Receptor Models","year":2018,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Engineering and Physical Sciences Research Council; Medical Research Council","keywords":"Homomeric; Kainate receptor; Biophysics; Chemistry; Ion channel; Gating; Receptor; Dimer; Xenopus; Molecular dynamics; Biochemistry; Biology; Glutamate receptor; AMPA receptor; Protein subunit; Computational chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008035348,0.0006416821,0.000500307,0.0003693975,0.0005537357,0.001018945,0.001342816,0.001007863,0.003095967],"category_scores_gemma":[0.000958337,0.0002670837,0.0004023149,0.0002393653,0.000506889,0.0007923715,0.0004127633,0.001391544,0.001335674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009952082,"about_ca_system_score_gemma":0.0003941121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094956,"about_ca_topic_score_gemma":0.0007205465,"domain_scores_codex":[0.9994493,0.0001177649,0.00005392446,0.0001095473,0.0002039932,0.00006543087],"domain_scores_gemma":[0.9994202,0.0001520541,0.000079733,0.0001306617,0.0001469826,0.00007038158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003702105,0.0001872609,0.000161122,0.00005771595,0.00002800527,0.0001064802,0.0000563192,0.002183214,0.9916999,0.003196982,0.000320214,0.001632487],"study_design_scores_gemma":[0.0001202315,0.0003409653,0.0008093443,0.00001175201,0.00005367388,0.0003711744,0.00009737074,0.06216863,0.9295871,0.001090294,0.005319713,0.00002980288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977027,0.000431837,0.01855506,0.0004077043,0.0002048888,0.0000530946,0.0007328585,0.0002693234,0.002318403],"genre_scores_gemma":[0.9891604,0.0003122143,0.006931229,0.00008116366,0.00001977424,0.0000602857,0.0009634513,0.0001974693,0.002274012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003095967,"threshold_uncertainty_score":0.01035702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01980017745609683,"score_gpt":0.2425231899921552,"score_spread":0.2227230125360584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}