{"id":"W4230117933","doi":"10.1016/j.atherosclerosissup.2017.08.003","title":"Apolipoprotein C-III inhibition with volanesorsen in patients with hypertriglyceridemia (COMPASS): A randomized, double-blind, placebo-controlled trial","year":2017,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; Mendelian randomization; Genome-wide association study; Lipoprotein lipase; Medicine; Bioinformatics; Hypertriglyceridemia; Exome; Apolipoprotein B; Exome sequencing; Internal medicine; Biology; Genetics; Lipoprotein; Cholesterol; Triglyceride; Single-nucleotide polymorphism; LDL receptor; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009226063,0.00054388,0.001963916,0.000265403,0.0004013382,0.0001957814,0.0002726098,0.0001933506,0.000449238],"category_scores_gemma":[0.0001472672,0.0003431538,0.0002615573,0.0001659373,0.0003090172,0.0005194171,0.0001068497,0.0003343627,0.00004759351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001131692,"about_ca_system_score_gemma":0.0001769021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003341,"about_ca_topic_score_gemma":0.0008888688,"domain_scores_codex":[0.9964682,0.0001929297,0.000933139,0.0006997619,0.0009753174,0.0007306593],"domain_scores_gemma":[0.9975794,0.0001078334,0.0007547141,0.001093507,0.0001900296,0.0002745177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9004371,0.001233826,0.09683982,0.00003234145,0.0003492163,0.000003644573,0.0002741595,0.000006022921,0.0001205787,0.00008361791,0.0003631974,0.000256486],"study_design_scores_gemma":[0.9705115,0.001181596,0.02589717,0.0002645726,0.0006434662,0.000001490123,0.0001074477,0.00005699807,0.0004756957,0.00003110923,0.0004160474,0.000412915],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795791,0.00002654638,0.00008269359,0.0005896412,0.0003014052,0.01811792,0.00004520702,0.00006861932,0.001188884],"genre_scores_gemma":[0.9939725,0.00003676854,0.0005668317,0.0003094664,0.0003043825,0.003911278,0.0003454792,0.00009120946,0.0004620256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07094264,"threshold_uncertainty_score":0.9999021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327038159583107,"score_gpt":0.2711368878988437,"score_spread":0.2478665063030126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}