{"id":"W4230117933","doi":"10.1016/j.atherosclerosissup.2017.08.003","title":"Apolipoprotein C-III inhibition with volanesorsen in patients with hypertriglyceridemia (COMPASS): A randomized, double-blind, placebo-controlled trial","year":2017,"lang":"en","type":"article","venue":"Atherosclerosis Supplements","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; Mendelian randomization; Genome-wide association study; Lipoprotein lipase; Medicine; Bioinformatics; Hypertriglyceridemia; Exome; Apolipoprotein B; Exome sequencing; Internal medicine; Biology; Genetics; Lipoprotein; Cholesterol; Triglyceride; Single-nucleotide polymorphism; LDL receptor; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122685,0.002341553,0.00471654,0.00059178,0.0006003724,0.001387316,0.0009061072,0.002241499,0.005942796],"category_scores_gemma":[0.001118638,0.0009419023,0.00269793,0.0005516945,0.001324754,0.0012184,0.0004913856,0.003187653,0.001161284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004963268,"about_ca_system_score_gemma":0.0009106246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245762,"about_ca_topic_score_gemma":0.002261535,"domain_scores_codex":[0.9995759,0.0001557308,0.0000419631,0.0000969715,0.00003755129,0.00009191711],"domain_scores_gemma":[0.9995449,0.0001074649,0.00009818761,0.00003563561,0.00004104917,0.0001726087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9871753,0.002278461,0.0002947655,0.0006747157,0.00132503,0.00003478144,0.00002690627,0.00008915382,0.00140672,0.00005861662,0.0003614814,0.006273966],"study_design_scores_gemma":[0.9793219,0.01834071,0.0008846628,0.00003806621,0.0007012101,0.00001707476,0.00002140165,0.0001358562,0.0001823583,0.00006416456,0.0002816507,0.00001096406],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742879,0.01591748,0.001002626,0.0009636033,0.001348763,0.002613892,0.0009434051,0.0003014036,0.002620962],"genre_scores_gemma":[0.9759275,0.01115491,0.001850639,0.001885092,0.0009908942,0.002589785,0.001200966,0.00004532151,0.004354981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005942796,"threshold_uncertainty_score":0.01988059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327038159583107,"score_gpt":0.2711368878988437,"score_spread":0.2478665063030126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}