{"id":"W4230373848","doi":"10.1002/ange.202013302","title":"DNA Triplex and Quadruplex Assembled Nanosensors for Correlating K<sup>+</sup> and pH in Lysosomes","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Nanosensor; Luminophore; Chemistry; Nanoparticle; Luminescence; Luminescent Measurements; DNA; Photon upconversion; G-quadruplex; Biophysics; Ion; Nanotechnology; Combinatorial chemistry; Biochemistry; Materials science; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003555074,0.0002382524,0.0002373995,0.000250736,0.0001244181,0.0004113751,0.0003408424,0.0005605585,0.000342513],"category_scores_gemma":[0.0003924886,0.000230878,0.0001482781,0.0001735316,0.0002887903,0.0004324826,0.0002928698,0.00032804,0.0002025799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004703971,"about_ca_system_score_gemma":0.000212723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002914603,"about_ca_topic_score_gemma":0.0006354955,"domain_scores_codex":[0.9997348,0.00004871695,0.0000180587,0.00009289607,0.00008230011,0.00002305487],"domain_scores_gemma":[0.999778,0.00004915204,0.00005912036,0.00001450677,0.00005683863,0.00004236152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000331455,0.000006379284,0.00009711012,0.00002196602,0.000002895172,0.00001581625,0.00001674633,0.0001295667,0.9987907,0.00005256855,0.0000165043,0.0008166722],"study_design_scores_gemma":[0.000003166236,0.00004262708,0.0002009424,0.000001394506,0.000002690796,0.00002976772,0.00001094599,0.001036583,0.9984133,0.00001650924,0.0002374645,0.000004524231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572501,0.001318637,0.03994023,0.0001529911,0.00004962171,0.0001020083,0.0002816677,0.0002530093,0.0006517026],"genre_scores_gemma":[0.9402286,0.0007570054,0.05607978,0.0001010054,0.000009339838,0.0001386807,0.0002222612,0.0000269419,0.002436369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005605585,"threshold_uncertainty_score":0.003413022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943033906017296,"score_gpt":0.2674146756172142,"score_spread":0.2479843365570412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}