{"id":"W4230427223","doi":"10.1002/ange.201102579","title":"Tuning DNA Stability To Achieve Turnover in Template for an Enzymatic Ligation Reaction","year":2011,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Ligation; DNA; Template; Chemical ligation; Enzyme; Combinatorial chemistry; Biophysics; Biochemistry; Materials science; Nanotechnology; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009477255,0.0004799505,0.0004541622,0.0003268958,0.0003518137,0.001058906,0.0006414311,0.0008471572,0.00266355],"category_scores_gemma":[0.002185227,0.0004794403,0.0003280762,0.0003546191,0.0003305016,0.000738391,0.0005117533,0.001119885,0.0016295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005383508,"about_ca_system_score_gemma":0.0005029598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003377818,"about_ca_topic_score_gemma":0.0007711327,"domain_scores_codex":[0.999097,0.0001449256,0.0001063168,0.0002682835,0.000256227,0.0001272502],"domain_scores_gemma":[0.9992676,0.0002667925,0.0001346819,0.0001076696,0.000144921,0.00007825804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005080071,0.0000216662,0.00008765873,0.00004882518,0.000005586557,0.00001988286,0.00004482707,0.000178528,0.9973017,0.0001955558,0.0000685479,0.001976372],"study_design_scores_gemma":[0.000005729337,0.00006659645,0.0001280604,0.000003105708,0.000005374674,0.0000295227,0.00000911225,0.001104279,0.9971083,0.00005461289,0.001477592,0.000007843768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9093857,0.002362426,0.08201855,0.0004236635,0.0001989803,0.0002064702,0.0003313819,0.001122099,0.003950634],"genre_scores_gemma":[0.9589876,0.0009302811,0.03461152,0.0001828983,0.00002180034,0.0001828803,0.0004844847,0.0003493654,0.004249138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266355,"threshold_uncertainty_score":0.008910477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06482124198842854,"score_gpt":0.2808592474404953,"score_spread":0.2160380054520668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}