{"id":"W4230490628","doi":"10.1002/ange.201805532","title":"Polyvalent Spherical Nucleic Acids for Universal Display of Functional DNA with Ultrahigh Stability","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Nucleic acid; Nanomaterials; Conjugate; Chemistry; Covalent bond; Polymer; Combinatorial chemistry; Nanotechnology; Avidity; Nucleic acid thermodynamics; Substrate (aquarium); Colloidal gold; Surface modification; Nucleotide; Nanoparticle; Materials science; Base sequence; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008524344,0.0001319516,0.000153873,0.00001508102,0.00006608723,0.000006263298,0.00008967408,0.0001099237,0.0000176093],"category_scores_gemma":[0.00003297118,0.00009946111,0.0001047474,0.00009702103,0.0003703391,0.000004551135,0.00003639928,0.00004280294,7.032825e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002173238,"about_ca_system_score_gemma":0.00004913093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007496252,"about_ca_topic_score_gemma":0.00003306939,"domain_scores_codex":[0.9992583,0.0000118298,0.0001381176,0.0003032863,0.0001146647,0.0001737366],"domain_scores_gemma":[0.9993703,0.00001469835,0.00008254974,0.0002662625,0.0002077936,0.00005835142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005458636,0.00008190569,0.001671503,0.00001650497,0.00007483487,4.880208e-7,0.00001601275,4.450517e-7,0.9964093,0.00002726978,0.0009128039,0.0002430448],"study_design_scores_gemma":[0.0004152357,0.0006792961,0.001039661,0.00001141496,0.00005757522,0.000005823274,0.0000791558,0.000005104649,0.9871505,0.00003895773,0.01037486,0.0001423988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848687,0.0000505477,0.01396231,0.0001075822,0.00003821675,0.0001248206,0.00007792326,0.00002689879,0.0007430188],"genre_scores_gemma":[0.9920537,0.00002189988,0.007121592,0.00008528026,0.000258975,0.000005938888,0.000163191,0.00001478478,0.0002746569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009462051,"threshold_uncertainty_score":0.4055906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371308431757886,"score_gpt":0.2462738891802097,"score_spread":0.2325608048626309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}