{"id":"W4230490628","doi":"10.1002/ange.201805532","title":"Polyvalent Spherical Nucleic Acids for Universal Display of Functional DNA with Ultrahigh Stability","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Nucleic acid; Nanomaterials; Conjugate; Chemistry; Covalent bond; Polymer; Combinatorial chemistry; Nanotechnology; Avidity; Nucleic acid thermodynamics; Substrate (aquarium); Colloidal gold; Surface modification; Nucleotide; Nanoparticle; Materials science; Base sequence; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914665,0.0002913759,0.0001264468,0.0002162173,0.0001338768,0.0002824175,0.0002985715,0.0003774727,0.001061276],"category_scores_gemma":[0.0002513964,0.0001769011,0.0001726898,0.000124882,0.0002210806,0.0002501829,0.000360156,0.000346906,0.0006644369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003907184,"about_ca_system_score_gemma":0.0001702595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002737958,"about_ca_topic_score_gemma":0.0007158697,"domain_scores_codex":[0.9998398,0.00002810174,0.00001138331,0.00003882084,0.00006068893,0.00002116455],"domain_scores_gemma":[0.9998652,0.00002974606,0.00002957716,0.00002269819,0.00002866744,0.00002401878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009175991,0.000004483166,0.00001835665,0.00001567748,0.000002005926,0.000008787865,0.000008449386,0.0001038128,0.9978821,0.000294644,0.00003499599,0.001617496],"study_design_scores_gemma":[0.000003212309,0.00003685665,0.00008687459,0.000001272408,0.000002740039,0.0000316744,0.000002571393,0.001371066,0.9967712,0.00004495885,0.001644422,0.000003112692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8388754,0.003655757,0.1498644,0.0004248611,0.0001571113,0.0001203337,0.0002946159,0.0009952455,0.005612342],"genre_scores_gemma":[0.9414821,0.0007459368,0.05272417,0.0001271576,0.00002427417,0.00006824239,0.0002444789,0.00007019249,0.004513445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061276,"threshold_uncertainty_score":0.003550351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371308431757886,"score_gpt":0.2462738891802097,"score_spread":0.2325608048626309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}