{"id":"W4230528385","doi":"10.1002/ange.201510494","title":"Use of Trifluoromethyl Groups for Catalytic Benzylation and Alkylation with Subsequent Hydrodefluorination","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Alkylation; Chemistry; Alkyl; Aryl; Electrophile; Trifluoromethyl; Medicinal chemistry; Catalysis; Friedel–Crafts reaction; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002695652,0.0004506729,0.0002015923,0.0002192486,0.0001464003,0.0001034908,0.0003229204,0.0002992803,0.002522727],"category_scores_gemma":[0.0003412938,0.0001179901,0.0001890675,0.0001441298,0.0001989827,0.0002430194,0.0003109474,0.0003925306,0.0006467279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687966,"about_ca_system_score_gemma":0.0003023421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006651436,"about_ca_topic_score_gemma":0.001089135,"domain_scores_codex":[0.9998287,0.00002338625,0.0000149312,0.00002888213,0.00004115374,0.00006296693],"domain_scores_gemma":[0.999836,0.00003525124,0.00004906721,0.0000305748,0.00002381343,0.00002526843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001847589,0.0000190171,0.0001069775,0.0001046261,0.0000100628,0.0001160645,0.00003054133,0.0001120261,0.9928167,0.0003316425,0.0001415719,0.006026005],"study_design_scores_gemma":[0.00001283932,0.0001874417,0.0004502301,0.000007079226,0.000008864744,0.0002185759,0.000006287148,0.0002001991,0.9965177,0.00003710414,0.002346932,0.000006818584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663806,0.00253453,0.01972667,0.0002564675,0.00008711316,0.0001064719,0.0004621123,0.0003477764,0.0100982],"genre_scores_gemma":[0.9921144,0.0008845291,0.005112017,0.00005874624,0.00001485274,0.00002493503,0.0002607077,0.0000354957,0.001494175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002522727,"threshold_uncertainty_score":0.008439422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1823034024761484,"score_gpt":0.3842114760967686,"score_spread":0.2019080736206202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}