{"id":"W4230853125","doi":"10.21203/rs.3.rs-94157/v1","title":"Gene Engineered Mesenchymal Stem Cells: Greater Transgene Expression and Efficacy With Minicircle Vs. Plasmid DNA Vectors in a Mouse Model of Acute Lung Injury","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Core Research for Evolutional Science and Technology; Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine","keywords":"Transgene; Minicircle; Mesenchymal stem cell; Plasmid; Gene; Genetic enhancement; Biology; Genetically modified mouse; Bystander effect; Molecular biology; Lung; Gene expression; Cell biology; Cancer research; Immunology; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000611574,0.0007401733,0.0005833533,0.0007956075,0.0002155247,0.0006128293,0.0005105491,0.0008473598,0.004669954],"category_scores_gemma":[0.000376364,0.0003333401,0.00040291,0.0004837794,0.0009285171,0.0008956754,0.0003488371,0.001998043,0.00120276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004022624,"about_ca_system_score_gemma":0.0005249462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051819,"about_ca_topic_score_gemma":0.00091036,"domain_scores_codex":[0.9992284,0.00008444378,0.0000864041,0.0002111492,0.0002721977,0.0001175644],"domain_scores_gemma":[0.9994699,0.00009848249,0.0001605874,0.00005207069,0.00006203458,0.0001568754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002504297,0.0000585401,0.00005186415,0.0000603168,0.000005608185,0.00002278962,0.00002660994,0.00005193483,0.9975926,0.0002285119,0.00009703129,0.001553654],"study_design_scores_gemma":[0.00003762151,0.0004352691,0.0007189393,0.00001049491,0.00001671439,0.0001030892,0.00001977902,0.0003627113,0.9965102,0.0000454138,0.001734629,0.00000498649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683776,0.00258808,0.02048346,0.000788712,0.0003290507,0.000158355,0.002840394,0.0006945973,0.00373976],"genre_scores_gemma":[0.9521477,0.002209145,0.02248907,0.0001884936,0.00009040037,0.0002739233,0.00262706,0.0004191925,0.01955509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004669954,"threshold_uncertainty_score":0.01562262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07992086347986985,"score_gpt":0.3515822188601956,"score_spread":0.2716613553803258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}