{"id":"W4230887734","doi":"10.32920/ryerson.14644383","title":"Clathrin and TOM1L1 regulate epidermal growth factor receptor signaling at the plasma membrane","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Clathrin; Cell biology; Protein kinase B; Epidermal growth factor; Endocytosis; Phosphorylation; Signal transduction; Epidermal growth factor receptor; Biology; Signal transducing adaptor protein; ERBB3; Chemistry; Receptor tyrosine kinase; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008339925,0.000301168,0.0002563903,0.00001807805,0.0001222829,0.0001013809,0.0002047247,0.0005785662,0.0004024508],"category_scores_gemma":[0.00008041585,0.000202397,0.0001451751,0.00004513581,0.0001179788,0.000003797459,0.001141321,0.0002910296,0.000004383638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000021017,"about_ca_system_score_gemma":0.00004644472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002827761,"about_ca_topic_score_gemma":0.00002047481,"domain_scores_codex":[0.9985774,0.00009033442,0.000294259,0.0006515856,0.0001478632,0.000238569],"domain_scores_gemma":[0.9992528,0.00002383752,0.0001440649,0.0003639854,0.000112812,0.0001024991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006856053,0.00000668837,0.0004204559,0.00009827246,0.00007562668,0.000001609271,0.0000508338,0.00001230634,0.9978495,0.000021288,0.0002807457,0.001114152],"study_design_scores_gemma":[0.0002006315,0.00002856666,0.002106374,0.00003779661,0.00002364939,0.00002444919,0.00002556595,0.0001178328,0.9951881,0.00004890768,0.001894723,0.0003034018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970021,0.0006155929,0.000145222,0.001327591,0.0003379926,0.0002154621,0.0001025433,0.00002146063,0.0002319897],"genre_scores_gemma":[0.992538,0.0007262266,0.000689882,0.0004028526,0.0004552677,0.00001826548,0.002334907,0.00002798624,0.002806586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00446412,"threshold_uncertainty_score":0.825351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115681485493633,"score_gpt":0.2202993995800752,"score_spread":0.2087312510307119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}