{"id":"W4230896764","doi":"10.1101/2020.05.15.098400","title":"Dopaminergic neuromodulation of spike timing dependent plasticity in mature adult rodent and human cortical neurons","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; University of Oxford; Aarhus Universitetshospital; Aarhus Universitet","keywords":"Neuroscience; Excitatory postsynaptic potential; Neuromodulation; Long-term potentiation; Synaptic plasticity; Metaplasticity; Neuroplasticity; Dopaminergic; Biology; Dopamine; Inhibitory postsynaptic potential; Stimulation; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008000861,0.00008638737,0.0001356167,0.0001102795,0.00004837299,0.0001438597,0.00009654965,0.0001180882,0.001273674],"category_scores_gemma":[0.0001511937,0.00005750395,0.0000982713,0.00008506439,0.00009229167,0.00007393319,0.00009249493,0.000211968,0.0001993418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001213109,"about_ca_system_score_gemma":0.0001119332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000835173,"about_ca_topic_score_gemma":0.001337726,"domain_scores_codex":[0.9999695,0.000003409472,0.00000323957,0.000008859571,0.000008220249,0.000006778851],"domain_scores_gemma":[0.9999681,0.000007313748,0.000007254182,0.000005238507,0.000005301122,0.000006837686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003310952,0.00003790417,0.0018702,0.00005655827,0.00001717781,0.0002485799,0.00004441728,0.000148299,0.987386,0.00017976,0.0002137714,0.009466343],"study_design_scores_gemma":[0.00005251594,0.0009587561,0.1432732,0.00002196775,0.00003626433,0.002070879,0.0001405694,0.002346901,0.8460144,0.0003773954,0.004694692,0.00001245515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941467,0.001351941,0.001949297,0.00005540297,0.00001492703,0.00001961158,0.0007343409,0.00004005384,0.00168756],"genre_scores_gemma":[0.9971208,0.0005482637,0.0008806262,0.00002879194,0.000003037227,0.00002046194,0.0005212957,0.000006886466,0.0008697796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273674,"threshold_uncertainty_score":0.004260838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04446105673675719,"score_gpt":0.292568296387598,"score_spread":0.2481072396508408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}