{"id":"W4230911957","doi":"10.1038/bjc.2015.81","title":"A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer","year":2015,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Kingston General Hospital; Centre Hospitalier de l’Université de Montréal; Queen's University","funders":"Fonds de Recherche du Québec - Santé; Queen's University; Ontario Institute for Cancer Research; Government of Ontario; Cancer Research Society","keywords":"Tumor microenvironment; Ovarian cancer; Immune system; Biology; Gene signature; Gene expression profiling; Cancer research; Tissue microarray; Chemotherapy; Serous fluid; Microarray analysis techniques; Cancer; Immunology; Gene expression; Medicine; Immunohistochemistry; Pathology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003638323,0.0001651941,0.0004516814,0.00009254767,0.00007171711,0.00005721175,0.0001111625,0.00007317715,0.0002635799],"category_scores_gemma":[0.0001291835,0.0001600332,0.00009695649,0.0001732162,0.0000763642,0.0001579255,0.00001606093,0.000520115,0.000001533059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001066995,"about_ca_system_score_gemma":0.0005938838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002955811,"about_ca_topic_score_gemma":0.01414347,"domain_scores_codex":[0.998381,0.00006734126,0.0005788337,0.0001973304,0.0004896792,0.000285876],"domain_scores_gemma":[0.9987996,0.00004349354,0.0005840997,0.0001043258,0.0002537864,0.0002146484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01224008,0.002726776,0.6558315,0.0004221616,0.002578812,0.01329822,0.01047304,0.001811723,0.1929075,0.00005681125,0.04903758,0.05861581],"study_design_scores_gemma":[0.01223549,0.0004296305,0.9164652,0.008339393,0.0002154778,0.001144569,0.0001894871,0.00006848241,0.01808617,0.0001110156,0.04238378,0.0003312834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917706,0.005228914,0.00009558303,0.002007584,0.0002988858,0.0002036563,0.0001264737,0.00001555043,0.0002527189],"genre_scores_gemma":[0.9960455,0.0008763957,0.0005888443,0.0006762586,0.000691595,0.00002836776,0.000006056595,0.00004807748,0.00103887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2606337,"threshold_uncertainty_score":0.789239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198028542356665,"score_gpt":0.2772199278630439,"score_spread":0.2574170736273774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}