{"id":"W4231034513","doi":"10.3410/f.716347801.791752801","title":"Faculty Opinions recommendation of Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.","year":2012,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Regulator; Downregulation and upregulation; Cystic fibrosis transmembrane conductance regulator; Heart failure; Sphingosine-1-phosphate; Pathological; Sphingosine; Sphingolipid; Tumor necrosis factor α; Transmembrane protein; Tumor necrosis factor alpha; Fibrosis; Medicine; Cell biology; Chemistry; Internal medicine; Cancer research; Endocrinology; Biology; Cystic fibrosis; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001022866,0.001265971,0.001140266,0.002730757,0.0004770703,0.00167219,0.001702663,0.001899127,0.03113911],"category_scores_gemma":[0.007649257,0.0003523474,0.001421139,0.003965109,0.0002562565,0.0007451742,0.001063879,0.001242549,0.02521869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001174579,"about_ca_system_score_gemma":0.00260554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02321644,"about_ca_topic_score_gemma":0.05706253,"domain_scores_codex":[0.9990865,0.0001502415,0.0001344839,0.0002649736,0.0002615851,0.0001022325],"domain_scores_gemma":[0.9973915,0.0008067844,0.0004625344,0.0004097017,0.000601998,0.0003274802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003502763,0.00005250626,0.00491649,0.001511209,0.0001942775,0.0000560896,0.00002081188,0.0003445833,0.0003548476,0.0003060971,0.9852318,0.006660974],"study_design_scores_gemma":[0.001216674,0.00008334409,0.03621044,0.000871871,0.0004602924,0.0003055903,0.00009842057,0.00189244,0.001811076,0.001174109,0.955801,0.00007475256],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0007086605,0.0002287582,0.00006426015,0.0001857419,0.00003277071,0.00001545117,0.9979365,0.0001879744,0.0006399959],"genre_scores_gemma":[0.001667608,0.0001732445,0.0003294978,0.0001150296,0.0000149981,0.000065557,0.9966096,0.00003188966,0.0009926463],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03113911,"threshold_uncertainty_score":0.1041707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03560148581036988,"score_gpt":0.3395567792218411,"score_spread":0.3039552934114712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}