{"id":"W4231042054","doi":"10.1038/s41589-019-0267-9","title":"Structure and functional reselection of the Mango-III fluorogenic RNA aptamer","year":2019,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Argonne National Laboratory; Office of Research Infrastructure Programs, National Institutes of Health; Lawrence Berkeley National Laboratory; National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Agence Nationale de la Recherche; Office of Science; National Institutes of Health; National Heart, Lung, and Blood Institute; U.S. Department of Energy","keywords":"Aptamer; RNA; Chemistry; Fluorescence; Pseudoknot; Crystallography; Mutant; Biophysics; Pyrimidine; Stereochemistry; Biochemistry; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446924,0.0002064298,0.0001887838,0.0001666952,0.0002795244,0.0002007418,0.0002635238,0.0002336437,0.0008774787],"category_scores_gemma":[0.0002623716,0.0001500148,0.0002501577,0.00009294612,0.0002236088,0.000126748,0.0001239866,0.0003677895,0.0003446749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003542325,"about_ca_system_score_gemma":0.0002137057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008761766,"about_ca_topic_score_gemma":0.00110564,"domain_scores_codex":[0.999798,0.00002804049,0.00001304322,0.00006071163,0.00005205987,0.00004821684],"domain_scores_gemma":[0.9998897,0.00002811842,0.00002316077,0.00002255508,0.00001602451,0.00002043816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002188563,0.000006716195,0.00004865515,0.000007707649,0.000001150917,0.00001855816,0.000009057283,0.00006677954,0.9992879,0.00009874639,0.00001333104,0.0004195118],"study_design_scores_gemma":[0.000002371729,0.00003758476,0.000306149,5.491844e-7,0.00000232639,0.00004936929,0.000002870202,0.0003413147,0.9988682,0.00001552177,0.0003717639,0.000001929517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879426,0.0002924024,0.009481552,0.0001056869,0.00002845985,0.00004869252,0.0001504435,0.0001418995,0.001808234],"genre_scores_gemma":[0.991613,0.00009866162,0.006195592,0.00006827388,0.000006669221,0.00002103628,0.0002136922,0.00003652953,0.001746551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008774787,"threshold_uncertainty_score":0.00293541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003295170716089781,"score_gpt":0.238446587837957,"score_spread":0.2351514171218672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}