{"id":"W4231058232","doi":"10.1172/jci200213265","title":"Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Michael's Hospital; Toronto General Hospital; Heart and Stroke Foundation; University of Toronto","funders":"Medical Research Council; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Peroxynitrite; Block (permutation group theory); Chemistry; Heart block; Cardiology; Internal medicine; Medicine; Cell biology; Biology; Biochemistry; Electrocardiography; Superoxide; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000446422,0.0005733881,0.0003604314,0.0003248413,0.000214578,0.0002585733,0.000169726,0.0004755648,0.001289445],"category_scores_gemma":[0.0002583998,0.000331723,0.0002061424,0.0001480995,0.0005183084,0.000274864,0.0002097225,0.000851087,0.0004225645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749497,"about_ca_system_score_gemma":0.000161206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001058892,"about_ca_topic_score_gemma":0.0002819854,"domain_scores_codex":[0.9996873,0.00007332263,0.00004324678,0.00005551667,0.00005816227,0.00008240143],"domain_scores_gemma":[0.9996101,0.00006620086,0.0001352648,0.00003437457,0.00001931124,0.0001348114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003866001,0.0001376176,0.0004049611,0.00002859235,0.000006514909,0.0001978917,0.00002100318,0.00004559529,0.9974174,0.0001273933,0.00004263784,0.001183735],"study_design_scores_gemma":[0.0004355372,0.005466076,0.0134493,0.0000388877,0.00007521436,0.002963794,0.00009170613,0.001653781,0.9732888,0.0002371392,0.002283777,0.00001603193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956856,0.0005804846,0.002472087,0.0001161545,0.0000326958,0.00003908579,0.000167923,0.0001384818,0.0007676569],"genre_scores_gemma":[0.9929712,0.0007785261,0.002997627,0.0001220322,0.00002647659,0.00008445395,0.0003775113,0.00005740083,0.002584812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289445,"threshold_uncertainty_score":0.004313648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.116099788383746,"score_gpt":0.3646847971506252,"score_spread":0.2485850087668792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}