{"id":"W4231068650","doi":"10.2217/pgs.10.95","title":"Irinotecan Pharmacogenomics","year":2010,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; University of Alberta","keywords":"Irinotecan; Camptothecin; Pharmacogenomics; Pharmacology; Toxicity; Pharmacodynamics; Pharmacokinetics; Medicine; Biology; Internal medicine; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005711586,0.0009871522,0.00161446,0.001775484,0.0002052248,0.001037452,0.0009692361,0.001092265,0.003097268],"category_scores_gemma":[0.0005143755,0.0003099627,0.0004737945,0.002327763,0.0003741839,0.0009976474,0.0005226456,0.001393191,0.003379908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009632545,"about_ca_system_score_gemma":0.0008563767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058071,"about_ca_topic_score_gemma":0.001643557,"domain_scores_codex":[0.9998147,0.00003136655,0.00001573824,0.00003686945,0.00008513669,0.0000162334],"domain_scores_gemma":[0.9997903,0.0000662126,0.00003325327,0.00001022675,0.00007942725,0.00002065169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004820301,0.00008325303,0.0001867243,0.00644489,0.0001110317,0.0002541343,0.00002455994,0.0006498891,0.004428766,0.004450338,0.03660472,0.9467134],"study_design_scores_gemma":[0.0000137858,0.00005541871,0.0007515752,0.001006895,0.00007183727,0.001091907,0.00002302422,0.0001708306,0.001870284,0.002575082,0.9923515,0.00001787716],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002574215,0.9948774,0.000778022,0.0005589099,0.0002035673,0.00001037718,0.00006296383,0.00002396758,0.003227458],"genre_scores_gemma":[0.001022317,0.9958975,0.0005517036,0.0002004924,0.0001379808,0.00001100628,0.00008858995,0.000003056354,0.002087289],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003097268,"threshold_uncertainty_score":0.01036137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05423699310349483,"score_gpt":0.3789046687321295,"score_spread":0.3246676756286346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}