{"id":"W4231068650","doi":"10.2217/pgs.10.95","title":"Irinotecan Pharmacogenomics","year":2010,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; University of Alberta","keywords":"Irinotecan; Camptothecin; Pharmacogenomics; Pharmacology; Toxicity; Pharmacodynamics; Pharmacokinetics; Medicine; Biology; Internal medicine; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002789187,0.0007533957,0.001029905,0.0001417668,0.0001460088,0.0000772779,0.0009284538,0.0006659148,0.0001629813],"category_scores_gemma":[0.0000124873,0.0007538056,0.0008700851,0.000141644,0.00009086301,0.000003150358,0.0003971328,0.0007599139,0.0002021383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009669143,"about_ca_system_score_gemma":0.0009174735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007152974,"about_ca_topic_score_gemma":0.00001544468,"domain_scores_codex":[0.9976222,0.00008638638,0.0006353186,0.0008788184,0.0001569469,0.0006203614],"domain_scores_gemma":[0.9984068,0.00002473891,0.0004152029,0.0007685237,0.00007391308,0.0003108685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000260836,0.00008189819,1.3997e-7,0.001142446,0.0003980979,0.000009395394,0.000009851031,0.000002723442,0.05127223,0.00008068751,0.0008546977,0.9461218],"study_design_scores_gemma":[0.0004794705,0.00008836362,1.873377e-8,0.0001902522,0.001150674,0.0001514537,0.000002498191,0.000009212955,0.01474235,0.0000327989,0.9823221,0.0008307993],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001285665,0.9942433,0.0004017394,0.0000126805,0.002486265,0.0008509447,0.0005902051,0.00004052655,0.001245728],"genre_scores_gemma":[0.00002881773,0.9931498,0.0006359287,0.0005465557,0.003054053,0.0001757607,0.0009828383,0.0002957456,0.001130496],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9814674,"threshold_uncertainty_score":0.9994913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05423699310349483,"score_gpt":0.3789046687321295,"score_spread":0.3246676756286346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}