{"id":"W4231239449","doi":"10.21203/rs.2.12171/v5","title":"Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Orphan receptor; Retinoic acid; Chemistry; Receptor; Retinoic acid receptor; Cholesterol; Hydrolase; Biochemistry; Cell biology; Enzyme; Biology; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002714829,0.0003937522,0.0005304291,0.0003668364,0.0001816253,0.0003380439,0.0002321244,0.0005308454,0.004755261],"category_scores_gemma":[0.0002348401,0.0002206385,0.0004455473,0.0002057306,0.0003407138,0.0003079197,0.0003019031,0.0009721915,0.001275545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792201,"about_ca_system_score_gemma":0.0003801285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005704924,"about_ca_topic_score_gemma":0.0005911097,"domain_scores_codex":[0.9997262,0.00005698462,0.00002210361,0.00004029386,0.00005466555,0.000099741],"domain_scores_gemma":[0.9998829,0.00001831678,0.00002569771,0.00002282754,0.0000168535,0.00003337747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00308105,0.0001482245,0.00030022,0.00009313686,0.00003191867,0.0001096425,0.00003680367,0.00008629242,0.9913462,0.0001944863,0.0004580505,0.004113993],"study_design_scores_gemma":[0.0003901886,0.001192594,0.004826275,0.00001859911,0.00009288912,0.0002483015,0.000177183,0.0005867157,0.9859804,0.0004137863,0.006062717,0.00001029782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832811,0.004435918,0.004372847,0.001230253,0.0005982376,0.00004320323,0.001074226,0.0003356574,0.004628528],"genre_scores_gemma":[0.9747406,0.003420964,0.002961486,0.0004922769,0.0001315641,0.00009715627,0.001262529,0.0001320484,0.01676133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004755261,"threshold_uncertainty_score":0.01590794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04265762212291094,"score_gpt":0.3597222638184677,"score_spread":0.3170646416955567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}