{"id":"W4231342473","doi":"10.1182/blood.v112.11.3679.3679","title":"Identification of a Potent Natural Triterpenoid Inhibitor of Proteosome Chymotrypsin-Like Activity and NF-κB with Specific Anti-Myeloma Activity in Vitro and in Vivo","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Proteasome; Chemistry; Cancer research; Cyclin D1; Transactivation; Biochemistry; Biology; Molecular biology; Transcription factor; Cell cycle; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327334,0.0005345189,0.0003325038,0.0004278767,0.0001256526,0.000264621,0.0001734245,0.0001973848,0.002029891],"category_scores_gemma":[0.00009559579,0.0001525539,0.0003209365,0.0002910147,0.0001417917,0.0001563356,0.0001470635,0.000471039,0.0006145355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254823,"about_ca_system_score_gemma":0.000257836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003671481,"about_ca_topic_score_gemma":0.001041033,"domain_scores_codex":[0.9999462,0.000005409086,0.000004789818,0.000010823,0.00001765868,0.0000150677],"domain_scores_gemma":[0.9999106,0.00001392965,0.00001846923,0.00001396389,0.00001447821,0.00002865015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001806465,0.0001138297,0.0002157594,0.00006706715,0.00002043151,0.00006628415,0.000008281494,0.000307563,0.995104,0.00004640602,0.0001071198,0.003762564],"study_design_scores_gemma":[0.00009445666,0.001448199,0.002424984,0.000009745888,0.00005273464,0.0003474831,0.00001353558,0.000615802,0.990791,0.00004289561,0.004153428,0.000005799635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776179,0.005525877,0.009698287,0.0002102742,0.00004100122,0.0002593258,0.002423296,0.000274917,0.003949125],"genre_scores_gemma":[0.9803823,0.003646494,0.007321965,0.0001525786,0.00001660596,0.0001391708,0.003732778,0.00004381652,0.004564223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029891,"threshold_uncertainty_score":0.006790698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115432808960634,"score_gpt":0.2376429278570455,"score_spread":0.2264885997674392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}