{"id":"W4231350626","doi":"10.22541/au.158636276.66764704","title":"Characterization of the Mechanism of Action of RDR01752, a Novel Corrector of F508del-CFTR","year":2020,"lang":"en","type":"dataset","venue":"Authorea","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fundação para a Ciência e a Tecnologia; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics","keywords":"Cystic fibrosis; Mutation; Mechanism of action; Chemistry; Cancer research; Pharmacology; Medicine; Internal medicine; Gene; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120202,0.0003925432,0.0004146727,0.0001727533,0.0001430424,0.0002833696,0.000412301,0.0005392796,0.001570512],"category_scores_gemma":[0.0001830995,0.00009795329,0.0004791682,0.00009204417,0.0001743037,0.0002262982,0.0001093878,0.0004863783,0.0006876633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004234571,"about_ca_system_score_gemma":0.0002772612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007243865,"about_ca_topic_score_gemma":0.0005329456,"domain_scores_codex":[0.9998325,0.00002113542,0.00001951257,0.00003208983,0.00006933382,0.00002534727],"domain_scores_gemma":[0.9999027,0.00001596946,0.0000290758,0.00001307995,0.00002269458,0.00001647258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007020866,0.00001933513,0.0002007312,0.00005048772,0.000005595305,0.00008859393,0.000004578468,0.00007637274,0.9976639,0.00006351172,0.00004433837,0.001712436],"study_design_scores_gemma":[0.00004906669,0.001249551,0.003809095,0.00001679908,0.0000331923,0.001595782,0.00002825211,0.001278943,0.9872586,0.00002247026,0.004649537,0.00000871336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9841725,0.006636733,0.005100006,0.0002465028,0.00005245136,0.0001482065,0.001140488,0.00009148708,0.002411629],"genre_scores_gemma":[0.9859395,0.002183741,0.005537168,0.0001211066,0.00001649884,0.00008395743,0.002800841,0.00002978399,0.003287364],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.001570512,"threshold_uncertainty_score":0.005253911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04518517775601823,"score_gpt":0.3285920784825708,"score_spread":0.2834069007265526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}