{"id":"W4231384568","doi":"10.1096/fasebj.2019.33.1_supplement.809.7","title":"Hydrogen‐Deuterium Exchange Reveals Distinct Activation States of PLCβ2 BY G‐Proteins","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Phospholipase C; Gq alpha subunit; Chemistry; G protein; Diacylglycerol kinase; G protein-coupled receptor; Phosphatidylinositol; Pleckstrin homology domain; Receptor; Stereochemistry; Biochemistry; Signal transduction; Protein kinase C","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004091481,0.0001024269,0.0001148336,0.00002928692,0.00009187739,0.00002450205,0.0001633153,0.00006445283,0.0001860808],"category_scores_gemma":[0.00003329756,0.00007216149,0.000085413,0.00006409652,0.00004394914,0.000008074629,0.00005238729,0.0001054086,0.00001144848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001473747,"about_ca_system_score_gemma":0.00003568341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001008883,"about_ca_topic_score_gemma":0.000001159503,"domain_scores_codex":[0.999214,0.000110224,0.0002208545,0.0001232806,0.0001729527,0.0001586788],"domain_scores_gemma":[0.9993831,0.00001235699,0.0002455048,0.0002152422,0.00008547628,0.00005834623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007918302,0.00002327743,0.0008195809,0.00001987127,0.00003521732,7.179447e-7,0.00005904451,0.0001031073,0.9967038,0.00001685648,0.001008648,0.00113067],"study_design_scores_gemma":[0.0004102299,0.0001550712,0.0005992191,0.0000403762,0.00001066187,0.00003037015,0.00005223325,0.0001325634,0.9922206,0.0002404355,0.006012366,0.00009588591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993435,0.0006911592,0.005003314,0.0002749551,0.00006645056,0.0002184212,0.00003490078,0.000005085642,0.0002707042],"genre_scores_gemma":[0.9983101,0.00008741082,0.0001568672,0.0001527104,0.000192186,0.000006534755,0.000100057,0.00001450473,0.0009796073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005003718,"threshold_uncertainty_score":0.294266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009148015490616935,"score_gpt":0.2306521171738939,"score_spread":0.2215041016832769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}