{"id":"W4231637248","doi":"10.1016/j.clml.2019.07.097","title":"Efficacy and Safety of Single-Agent Quizartinib, a Potent and Selective FLT3 Inhibitor (FLT3i), in Patients (pts) With FLT3-Internal Tandem Duplication (FLT3-ITD) – Mutated Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) Enrolled in the Global, Phase 3, Randomized Controlled QuANTUM-R Trial","year":2019,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Myeloid leukemia; Refractory (planetary science); Medicine; Tandem exon duplication; Fms-Like Tyrosine Kinase 3; Oncology; Internal medicine; Pharmacology; Cancer research; Gene duplication; Mutation; Chemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001046421,0.0006225684,0.001813574,0.0002087332,0.0002493003,0.0008189579,0.000398387,0.0007191525,0.002021789],"category_scores_gemma":[0.001152195,0.0003201261,0.001483965,0.0003110758,0.000643854,0.0008590176,0.0002289583,0.001826385,0.0003179083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007432183,"about_ca_system_score_gemma":0.0008777899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009426195,"about_ca_topic_score_gemma":0.002889261,"domain_scores_codex":[0.9996386,0.0001631674,0.00002098075,0.00007802361,0.00003019546,0.00006913966],"domain_scores_gemma":[0.9996023,0.00009569731,0.0001135864,0.00002996739,0.00002604439,0.0001324371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9028785,0.004120855,0.009637625,0.0004779887,0.002118287,0.00008084787,0.0000695926,0.00193344,0.0100581,0.0002395071,0.002649437,0.06573585],"study_design_scores_gemma":[0.6515309,0.24545,0.08546098,0.00007644966,0.00488257,0.0004042479,0.000108588,0.004767908,0.003364263,0.0008171975,0.003050746,0.00008617742],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955543,0.00217297,0.0002092725,0.0003099712,0.00008013046,0.0001463589,0.0005737411,0.00003936402,0.000913933],"genre_scores_gemma":[0.9977745,0.0006034883,0.0001908588,0.0002825624,0.00005970588,0.00007844447,0.0006062309,0.000006551765,0.0003976467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021789,"threshold_uncertainty_score":0.006763577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163294114796837,"score_gpt":0.3141284784032331,"score_spread":0.2977990669235494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}