{"id":"W4231694933","doi":"10.3410/f.717955551.793460551","title":"Faculty Opinions recommendation of Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.","year":2012,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Muscular Dystrophy Association","keywords":"Malignant hyperthermia; Ryanodine receptor; Skeletal muscle; Coupling (piping); Type (biology); Internal medicine; Endocrinology; Medicine; Chemistry; Receptor; Biology; Cardiology; Pathology; Materials science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008370983,0.00121835,0.0009949347,0.002123273,0.0004884218,0.001582863,0.00189017,0.001609385,0.04838149],"category_scores_gemma":[0.008147774,0.0003612508,0.001218648,0.003014907,0.0001929731,0.0009132379,0.001369496,0.001054338,0.0295171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000998419,"about_ca_system_score_gemma":0.001795153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02100714,"about_ca_topic_score_gemma":0.05884324,"domain_scores_codex":[0.9991904,0.0001195375,0.0001039202,0.0002305754,0.0002512285,0.0001044439],"domain_scores_gemma":[0.9970452,0.001006619,0.0005036049,0.000433516,0.0006822526,0.0003288609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000184399,0.00002512216,0.005048093,0.001138843,0.0001020564,0.00004030159,0.00001725746,0.0002203651,0.0001571967,0.0002331745,0.9878071,0.005025972],"study_design_scores_gemma":[0.0006137786,0.00004020422,0.04978278,0.0006395039,0.0002526557,0.0002498853,0.0000976637,0.0008824884,0.0008785208,0.001055282,0.9454471,0.00006011586],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.000417991,0.000136793,0.00004896877,0.0001505321,0.00002830751,0.00001065014,0.9982584,0.000172553,0.0007758552],"genre_scores_gemma":[0.001914517,0.0001388216,0.0002424949,0.0001293695,0.00001703611,0.00005951565,0.9960423,0.00004628802,0.001409718],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.04838149,"threshold_uncertainty_score":0.1618522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0398570268412186,"score_gpt":0.3259126819106964,"score_spread":0.2860556550694778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}