{"id":"W4231881614","doi":"10.26434/chemrxiv.9964256.v1","title":"An Activity-Based Methionine Bioconjugation Approach to Developing Proximity-Activated Imaging Reporters","year":2019,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Life Sciences Research Foundation; Canadian Institute for Advanced Research; University of California Berkeley; Japan Society for the Promotion of Science; Howard Hughes Medical Institute","keywords":"Bioconjugation; Context (archaeology); Methionine; Chemistry; Biochemistry; Biophysics; Computational biology; Biology; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005678488,0.0008829117,0.0003502125,0.0003966985,0.0002517176,0.0004703698,0.0007300577,0.0007601438,0.0007067413],"category_scores_gemma":[0.0004774604,0.0004160693,0.0004268027,0.0002626199,0.0004328468,0.0005053065,0.0006639074,0.001293174,0.0004688683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003336151,"about_ca_system_score_gemma":0.0003066249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001956288,"about_ca_topic_score_gemma":0.0003191945,"domain_scores_codex":[0.9995996,0.00009695326,0.00002989712,0.0001196422,0.0001128302,0.00004104766],"domain_scores_gemma":[0.9998078,0.00004467171,0.00005041512,0.0000286241,0.00004130197,0.00002722686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001838097,0.00001381762,0.00004896508,0.00005978908,0.000005436793,0.00004068056,0.00002495543,0.0001282839,0.9951036,0.001068389,0.00005289699,0.00343479],"study_design_scores_gemma":[0.000004250921,0.000104858,0.00007593737,0.000003070072,0.00000649093,0.0001789756,0.000005841923,0.001047325,0.9955286,0.00009629862,0.002942249,0.000006108053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2612866,0.002813662,0.7293292,0.0005081896,0.0002132893,0.0002978992,0.0001795263,0.001071066,0.004300502],"genre_scores_gemma":[0.577511,0.003698019,0.4110387,0.000282272,0.00007182641,0.0003941626,0.0004253028,0.000120161,0.006458551],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0008829117,"threshold_uncertainty_score":0.00300312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04022625466852717,"score_gpt":0.3056459162969751,"score_spread":0.2654196616284479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}