{"id":"W4231919180","doi":"10.1080/13543776.2017.1297797","title":"Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 – <i>Part II</i>","year":2017,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Patents","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Trk receptor; Tropomyosin receptor kinase A; Drug development; Medicine; Pharmacology; Cancer research; Internal medicine; Drug; Receptor; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000603162,0.001050955,0.001639433,0.0001011115,0.0004954764,0.000093331,0.001310422,0.0007749268,0.0001780792],"category_scores_gemma":[0.000125062,0.0008281498,0.001160901,0.000101519,0.0001571366,0.00001761848,0.0002610068,0.0002944565,0.0001578753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001211577,"about_ca_system_score_gemma":0.0004972609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001368062,"about_ca_topic_score_gemma":5.408469e-7,"domain_scores_codex":[0.9956691,0.0005798985,0.001106857,0.001495623,0.0004425175,0.0007060456],"domain_scores_gemma":[0.9957774,0.00002901268,0.001070373,0.002467809,0.0002324328,0.0004229886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001552529,0.0006052016,0.000001018756,0.002393041,0.0003808665,0.000002643135,0.00001565981,2.017742e-7,0.001105456,0.00001191662,0.2189704,0.7763584],"study_design_scores_gemma":[0.0009516427,0.001219752,3.241861e-7,0.02803245,0.0001458209,0.000008838409,0.000004758779,0.000001665739,0.00336599,0.00001291655,0.9652947,0.0009611099],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001254613,0.9892749,0.00005502081,0.0002087107,0.006197838,0.00314669,0.0009566157,0.00007695684,0.00007074735],"genre_scores_gemma":[0.00001288793,0.9746252,0.0001511017,0.002271107,0.002494554,0.001829638,0.01689618,0.0002608507,0.00145847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7753972,"threshold_uncertainty_score":0.9994169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2270398082199384,"score_gpt":0.4052185314502031,"score_spread":0.1781787232302647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}