{"id":"W4231929371","doi":"10.1101/317164","title":"Genetic determinants of risk and survival in pulmonary arterial hypertension","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Deutsche Forschungsgemeinschaft; St. George's, University of London; Medical Research Council; American College of Clinical Pharmacy Research Institute; Nederlandse Federatie van Universitair Medische Centra; Dinosaur Trust; National Institutes of Health; ZonMw; National Institute for Health and Care Research; Georgia Clinical and Translational Science Alliance; Horizon 2020 Framework Programme; American College of Clinical Pharmacy; British Heart Foundation; University of Cambridge; Vanderbilt University Medical Center; King's College Hospital NHS Foundation Trust; Lloyd's Tercentenary Research Foundation; Wellcome Trust; King's College London; Vanderbilt University; Pulmonary Hypertension Association; American Heart Association","keywords":"Biology; Allele; Locus (genetics); Genetics; Enhancer; Genome-wide association study; Genotyping; Haplotype; Genetic association; Oncology; Genotype; Gene; Medicine; Single-nucleotide polymorphism; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009865349,0.0003316,0.0003613292,0.0007223609,0.0002694265,0.0005610251,0.0003652831,0.0005447585,0.001966077],"category_scores_gemma":[0.002013006,0.0001413977,0.0007809593,0.0009512415,0.0002906692,0.0002009695,0.0004608521,0.0005111475,0.0001461933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139705,"about_ca_system_score_gemma":0.0001545862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009790093,"about_ca_topic_score_gemma":0.0006073849,"domain_scores_codex":[0.999185,0.0003116344,0.00006177959,0.0002749584,0.00007521577,0.00009144811],"domain_scores_gemma":[0.9978277,0.001042038,0.0004981293,0.0002026526,0.0001146803,0.0003147273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005488823,0.00002350826,0.9908643,0.0000284043,0.0008398955,0.0002916764,0.00004016455,0.0002837199,0.003796067,0.00006411419,0.00008295498,0.003136257],"study_design_scores_gemma":[0.00002432038,0.0001040605,0.9961902,0.00001131422,0.0004604285,0.00073858,0.0000517066,0.00111156,0.0007583722,0.0002541232,0.0002879804,0.000007411839],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997494,0.001044953,0.0007441221,0.00006972434,0.00001208898,0.000002874781,0.0003925461,0.00001253358,0.0002271001],"genre_scores_gemma":[0.9994405,0.0001037036,0.0001489265,0.0000131515,0.00001490366,0.000002949704,0.0002059503,0.000003366943,0.00006648355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966077,"threshold_uncertainty_score":0.006577194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186336117090739,"score_gpt":0.2504887049254517,"score_spread":0.2286253437545443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}