{"id":"W4231941025","doi":"10.3410/f.1159380.619733","title":"Faculty Opinions recommendation of Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential.","year":2009,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"TRPV1; Calcitonin gene-related peptide; Calcitonin; Nociception; Botulinum toxin; Sensory system; Neuroscience; Chemistry; Medicine; Pharmacology; Receptor; Neuropeptide; Internal medicine; Psychology; Transient receptor potential channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0009063114,0.00215042,0.001421706,0.003673794,0.0005381394,0.001556827,0.002001466,0.002051791,0.03146141],"category_scores_gemma":[0.006509393,0.0004402101,0.001839808,0.005121355,0.0002622688,0.0009334713,0.001009756,0.001158876,0.02890104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00113699,"about_ca_system_score_gemma":0.002291387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02823265,"about_ca_topic_score_gemma":0.0524364,"domain_scores_codex":[0.9988268,0.0001679071,0.0002089118,0.0003702517,0.0003032708,0.0001228381],"domain_scores_gemma":[0.9974509,0.000794048,0.0004165242,0.0004573664,0.0006262449,0.0002548659],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003349983,0.00006439612,0.004963951,0.002208224,0.0002372084,0.00007925981,0.00001878658,0.0007149136,0.0004326863,0.0002987987,0.9816626,0.008984236],"study_design_scores_gemma":[0.0008240912,0.00006687324,0.03014751,0.0006119164,0.000376084,0.0002396525,0.0000669068,0.002824003,0.001667549,0.0009944561,0.9621065,0.00007442541],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"other","genre_scores_codex":[0.000489163,0.0001742893,0.00007688,0.00008816184,0.0000301345,0.00001427598,0.9982544,0.0002269141,0.0006458815],"genre_scores_gemma":[0.001138482,0.0001359946,0.0003180038,0.00005889059,0.000009780218,0.00004304761,0.9976318,0.00002867947,0.000635263],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9990937,"threshold_uncertainty_score":0.1052489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712209521872965,"score_gpt":0.3023752500440454,"score_spread":0.2852531548253158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}