{"id":"W4232210604","doi":"10.1002/ange.202004934","title":"Template‐Directed Copying of RNA by Non‐enzymatic Ligation","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Simons Foundation; Howard Hughes Medical Institute; National Science Foundation","keywords":"Oligonucleotide; Template; Ligation; RNA; Chemical ligation; Chemistry; Combinatorial chemistry; Computational biology; Biology; Biochemistry; DNA; Molecular biology; Nanotechnology; Gene; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004083911,0.00009558552,0.0001664743,0.0000141527,0.00004864713,0.00001513281,0.00008277517,0.00002863277,0.0005919138],"category_scores_gemma":[0.000006334179,0.00009271296,0.00006378011,0.0001520742,0.00002392104,0.00009473303,0.00002190623,0.0000751014,0.00004173055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000109623,"about_ca_system_score_gemma":0.00002634909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000830261,"about_ca_topic_score_gemma":2.759737e-7,"domain_scores_codex":[0.99942,0.000006538222,0.0001987916,0.0001325535,0.0001115754,0.0001305171],"domain_scores_gemma":[0.9996327,0.00002157641,0.000114955,0.00009381926,0.00004701742,0.00008999432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001787738,0.00007117074,0.01061457,0.0000881545,0.00008768772,5.240862e-7,0.0007566788,0.00002142764,0.8221875,0.0003215555,0.1648923,0.0009404777],"study_design_scores_gemma":[0.0003687426,0.00002477111,0.0001867691,0.00002978297,0.00002058028,9.741724e-8,0.0001563686,0.0003688672,0.9783635,0.0001381879,0.02023467,0.0001077095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587618,0.0001413447,0.003091881,0.001063397,0.00009949851,0.0001552213,0.0001544633,0.00008815707,0.03644421],"genre_scores_gemma":[0.9988849,0.000002998684,0.0003459536,0.0001246581,0.0002246579,0.000007565549,0.0001156298,0.00001210124,0.0002815589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1561759,"threshold_uncertainty_score":0.6481041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527225070448292,"score_gpt":0.2371699557547811,"score_spread":0.2218977050502982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}