{"id":"W4232263000","doi":"10.1016/j.bpj.2015.11.2746","title":"Mechanism of Cyclic AMP Partial Agonism in Protein Kinase G (PKG)","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"cGMP-dependent protein kinase; Protein kinase A; PDE10A; Intracellular; Chemistry; Cell biology; Signal transduction; Phosphodiesterase 3; Partial agonist; Cyclic nucleotide; Biophysics; Second messenger system; Agonist; Phosphorylation; Biochemistry; Receptor; Biology; Phosphodiesterase; Nucleotide; Cyclin-dependent kinase 2; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005012,0.00008648483,0.0001085133,0.00003639513,0.00003662136,0.0000103302,0.00008059625,0.00008602079,0.00003506499],"category_scores_gemma":[0.00003802004,0.00005505379,0.00009305735,0.00005253261,0.00006002469,0.000006279341,0.00003534834,0.00006526997,0.00001668764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001577698,"about_ca_system_score_gemma":0.00003946758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004405965,"about_ca_topic_score_gemma":0.000004767158,"domain_scores_codex":[0.9993264,0.0000590667,0.0002060877,0.0001351914,0.0001235327,0.0001496868],"domain_scores_gemma":[0.9996367,0.000005237597,0.0001054961,0.0001264319,0.0000468648,0.00007933546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001438874,0.0001057691,0.0001018811,0.000003509576,0.00001266528,0.00000421351,0.00001210365,0.000002543681,0.9947643,0.001286519,0.0001006081,0.003462014],"study_design_scores_gemma":[0.0008176973,0.0002071397,0.002016568,0.00004017393,0.000004810187,0.00001728172,0.000006075448,0.00001455464,0.9917284,0.000826953,0.004230071,0.00009022836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907104,0.00001784004,0.008515234,0.0003995106,0.0001819067,0.0000822098,0.000005395201,0.000003916291,0.00008361505],"genre_scores_gemma":[0.9988278,0.00002624669,0.0002224935,0.00005232546,0.0004150442,0.000006897516,0.000004890164,0.000008800206,0.0004355471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008292741,"threshold_uncertainty_score":0.2245028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110581189821126,"score_gpt":0.2404394149658169,"score_spread":0.2293812959837043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}