{"id":"W4232278611","doi":"10.1007/bf03259727","title":"Impact of Intravenous Naltrexone on Intravenous Morphine-Induced High, Drug Liking, and Euphoric Effects in Experienced, Nondependent Male Opioid Users","year":2011,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"Shionogi; Astellas Pharma; Purdue University; Eisai; Bayer HealthCare; Boston Scientific Corporation; Purdue Pharma; Gilead Sciences; GlaxoSmithKline; Nevro; Teva Pharmaceutical Industries; AstraZeneca; Pfizer","keywords":"Euphoriant; Naltrexone; Morphine; Medicine; Heroin; Anesthesia; Opioid; Narcotic antagonist; Visual analogue scale; Pharmacology; Drug; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002231793,0.0003848311,0.0007180068,0.0005730577,0.00003765472,0.00001230846,0.0001743458,0.0001494379,0.0001559254],"category_scores_gemma":[0.00007768692,0.0003244825,0.0001136441,0.0004730875,0.00008949805,0.00009912463,0.00007929846,0.0003847095,0.00002409319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005058937,"about_ca_system_score_gemma":0.0001972482,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01069556,"about_ca_topic_score_gemma":0.0002278123,"domain_scores_codex":[0.9979134,0.0000945924,0.0005000094,0.0005448883,0.0004034341,0.0005436448],"domain_scores_gemma":[0.9989283,0.0001242067,0.0001655014,0.000522072,0.00004928935,0.000210636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002773086,0.009903467,0.6413534,0.0008197724,0.0003791444,0.002157336,0.2890044,0.00008310922,0.02094052,0.000642423,0.0001057847,0.03183751],"study_design_scores_gemma":[0.006682643,0.003411312,0.9467455,0.0006546377,0.00007420383,0.0000942401,0.004186672,0.0001268874,0.03733695,0.0003262626,0.000004511252,0.0003561756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968446,0.000475852,0.000006498776,0.00004217097,0.0002527583,0.001144436,0.000009789041,0.00003767024,0.001186202],"genre_scores_gemma":[0.998722,0.0002548173,0.0006060619,0.00006198016,0.00004553242,0.0001490096,0.00001999325,0.00005329014,0.00008729783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3053921,"threshold_uncertainty_score":0.9999207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124207090589173,"score_gpt":0.2684139299841857,"score_spread":0.2559932209252684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}