{"id":"W4232278611","doi":"10.1007/bf03259727","title":"Impact of Intravenous Naltrexone on Intravenous Morphine-Induced High, Drug Liking, and Euphoric Effects in Experienced, Nondependent Male Opioid Users","year":2011,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"Shionogi; Astellas Pharma; Purdue University; Eisai; Bayer HealthCare; Boston Scientific Corporation; Purdue Pharma; Gilead Sciences; GlaxoSmithKline; Nevro; Teva Pharmaceutical Industries; AstraZeneca; Pfizer","keywords":"Euphoriant; Naltrexone; Morphine; Medicine; Heroin; Anesthesia; Opioid; Narcotic antagonist; Visual analogue scale; Pharmacology; Drug; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005675518,0.0002894646,0.0004085721,0.0001206218,0.0001421571,0.0002734486,0.00020688,0.0002883402,0.002217887],"category_scores_gemma":[0.001866482,0.0002002657,0.0003916677,0.00008875745,0.0003076595,0.0002700404,0.0001958432,0.0004859602,0.0001570702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992926,"about_ca_system_score_gemma":0.0001921216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003615385,"about_ca_topic_score_gemma":0.0007127988,"domain_scores_codex":[0.9995453,0.0002330897,0.00004546808,0.00004842204,0.00007889125,0.00004874209],"domain_scores_gemma":[0.9991003,0.00035645,0.0002282945,0.00005181682,0.00004014509,0.0002230026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.504052,0.0952432,0.08338332,0.001102246,0.0009946459,0.0004412752,0.0005294505,0.001302024,0.1914897,0.0001044796,0.0003353839,0.1210222],"study_design_scores_gemma":[0.01699993,0.7160161,0.2496439,0.00003014702,0.0002907943,0.0003580199,0.0001727773,0.001275239,0.01474881,0.00003201501,0.0004043664,0.00002793965],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997314,0.00005650135,0.00002177912,0.000006296005,0.000003401351,0.00003922874,0.0000242,0.000002399816,0.0001147897],"genre_scores_gemma":[0.9994519,0.00008023233,0.0001498207,0.00003155929,0.00001181372,0.0000450215,0.00005187051,0.000001356931,0.0001763452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002217887,"threshold_uncertainty_score":0.007419586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124207090589173,"score_gpt":0.2684139299841857,"score_spread":0.2559932209252684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}