{"id":"W4232358903","doi":"10.1158/1538-7445.am2019-1556","title":"Abstract 1556: Preclinical development of antibody drug conjugates targetting EGFRvIII","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody; Antibody-drug conjugate; Cancer research; In vivo; Epidermal growth factor receptor; Conjugate; Cancer; Chemistry; Monoclonal antibody; Molecular biology; Medicine; Biology; Immunology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017192,0.0004569601,0.0003393356,0.0003464446,0.0001437947,0.0002482845,0.0003740648,0.0003440049,0.003763071],"category_scores_gemma":[0.0001640269,0.0001842773,0.000251793,0.0001849277,0.0001074621,0.0001913058,0.0001310238,0.0006228405,0.0009910983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002763178,"about_ca_system_score_gemma":0.0003889767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007503951,"about_ca_topic_score_gemma":0.0008030066,"domain_scores_codex":[0.9999082,0.00001885743,0.000006935437,0.00001358268,0.00002607172,0.00002633496],"domain_scores_gemma":[0.9999423,0.000007970511,0.000009982323,0.000004880396,0.00001323288,0.00002156986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002389258,0.00297969,0.0004457809,0.0002827501,0.0000556346,0.0001657292,0.00006713668,0.001889645,0.9507623,0.0005750329,0.002942191,0.0374449],"study_design_scores_gemma":[0.001250993,0.04494337,0.003175141,0.00004068734,0.00009090854,0.0005209951,0.00002672349,0.002347789,0.9197043,0.0001148391,0.02776746,0.00001679739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965357,0.006389436,0.008019447,0.0003475076,0.0003022513,0.001397858,0.002136056,0.0004159652,0.01563451],"genre_scores_gemma":[0.9681383,0.004816231,0.005823211,0.0001627324,0.00006440868,0.0006502227,0.00319389,0.00004897656,0.01710207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003763071,"threshold_uncertainty_score":0.01258874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1575404227938784,"score_gpt":0.5331337627656179,"score_spread":0.3755933399717395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}