{"id":"W4232375200","doi":"10.1158/1538-7445.transcagen-a2-11","title":"Abstract A2-11: PLZF, a tumor suppressor genetically lost in metastatic castration resistant prostate cancer, is a mediator of resistance to androgen deprivation therapy","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Prostate cancer; Androgen deprivation therapy; Gene knockdown; Enzalutamide; Cancer research; Cancer; LNCaP; Suppressor; Androgen; Medicine; Biology; Androgen receptor; Internal medicine; Gene; Genetics; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006305206,0.0002857889,0.0002180925,0.0002877059,0.000283372,0.0002796513,0.000200888,0.0002490251,0.004823895],"category_scores_gemma":[0.00009700785,0.00007938505,0.0002119001,0.0002665345,0.0002006423,0.0001068258,0.0001463413,0.0005054149,0.001269444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003423284,"about_ca_system_score_gemma":0.0002057667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001504914,"about_ca_topic_score_gemma":0.001734633,"domain_scores_codex":[0.9999335,0.000004323353,0.000003948975,0.00001729132,0.00003224896,0.00000860488],"domain_scores_gemma":[0.9999433,0.000006495231,0.00001927691,0.000005370038,0.000007005406,0.00001852364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001534461,0.00001519833,0.001644886,0.00004147531,0.000007262,0.000377751,0.00001284907,0.0001332158,0.9934697,0.0001620194,0.0004941983,0.003488008],"study_design_scores_gemma":[0.0000828395,0.0003710881,0.0751289,0.00002427134,0.00007319741,0.007146775,0.0001118787,0.003415387,0.8877692,0.0003327277,0.02551953,0.00002406692],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845659,0.001537356,0.005332407,0.0003955598,0.00009064191,0.00004557562,0.004248261,0.0004330297,0.003351411],"genre_scores_gemma":[0.9836808,0.0006302275,0.001354461,0.0001214665,0.00002151606,0.00001990389,0.003425635,0.00005074566,0.01069511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004823895,"threshold_uncertainty_score":0.01613754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234461242108576,"score_gpt":0.4236204419105356,"score_spread":0.300174317699678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}