{"id":"W4232401843","doi":"10.1158/1535-7163.targ-09-a9","title":"Abstract A9: Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Pazopanib; Topotecan; Ovarian cancer; Medicine; Pharmacology; Paclitaxel; Chemotherapy; Ovarian carcinoma; Cancer; Bevacizumab; Oncology; Cancer research; Internal medicine; Sunitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641895,0.0005160947,0.0007726364,0.0004063569,0.0002297219,0.0004962998,0.0003855472,0.0003900554,0.001736556],"category_scores_gemma":[0.000197797,0.0002025288,0.0004093557,0.000287206,0.0002676397,0.0003082173,0.0001500928,0.001437675,0.0003268986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003726316,"about_ca_system_score_gemma":0.0008843767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001924393,"about_ca_topic_score_gemma":0.002981248,"domain_scores_codex":[0.9998236,0.00004169188,0.00001426654,0.00002614012,0.00003336378,0.00006087616],"domain_scores_gemma":[0.9998265,0.00002531537,0.0000247771,0.00001636701,0.00001711007,0.00008985783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01829857,0.01498495,0.001002254,0.0002893354,0.0001377287,0.0002531882,0.00007677695,0.00165158,0.9337694,0.0003414329,0.002153202,0.02704165],"study_design_scores_gemma":[0.005406508,0.1563245,0.01037908,0.00002552293,0.0003067295,0.0006199434,0.00006702462,0.003260584,0.8162324,0.0001528552,0.007191045,0.00003379759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936144,0.001726817,0.0006754398,0.0002656601,0.0001327687,0.000263241,0.001229238,0.00009819877,0.00199427],"genre_scores_gemma":[0.9940618,0.001148921,0.001142957,0.00008825857,0.00004651277,0.0001470239,0.001623724,0.00001945225,0.001721381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001924393,"threshold_uncertainty_score":0.005809367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545390850934368,"score_gpt":0.3495010082494963,"score_spread":0.3140470997401527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}