{"id":"W4232494513","doi":"10.3410/f.734915175.793555877","title":"Faculty Opinions recommendation of The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.","year":2019,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Tau Consortium; McDonnell Center for Systems Neuroscience; National Institutes of Health; JPB Foundation; Eli Lilly and Company; Deutsche Forschungsgemeinschaft; BrightFocus Foundation","keywords":"Wakefulness; Neurodegeneration; Cerebrospinal fluid; Interstitial fluid; Sleep deprivation; Endocrinology; Internal medicine; Glymphatic system; Sleep (system call); Circadian rhythm; Medicine; Neuroscience; Psychology; Disease; Electroencephalography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001851122,0.001449265,0.001257848,0.004237096,0.0006998452,0.002385362,0.001706006,0.001732727,0.0605041],"category_scores_gemma":[0.01449565,0.000405584,0.002082652,0.006041847,0.0003257947,0.001210927,0.001503711,0.001235414,0.04866469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00119265,"about_ca_system_score_gemma":0.003337723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01767277,"about_ca_topic_score_gemma":0.04406612,"domain_scores_codex":[0.9982705,0.0003721727,0.0003014702,0.0005101594,0.0003571573,0.0001885394],"domain_scores_gemma":[0.9942586,0.001875417,0.001091694,0.0007811242,0.001483518,0.0005094896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002948773,0.00003575341,0.007509525,0.004190531,0.0003620183,0.00003954392,0.00003840093,0.0002747679,0.0003358397,0.0004583248,0.9756471,0.01081321],"study_design_scores_gemma":[0.0006313536,0.0000512654,0.02589113,0.001599859,0.0004818468,0.0001158514,0.00006963861,0.0006966601,0.0005677521,0.0009924823,0.9688524,0.00004976657],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0004773541,0.0005699793,0.00008613832,0.0003109827,0.00005667998,0.00002386058,0.9970253,0.0002535767,0.001196159],"genre_scores_gemma":[0.001956756,0.0004339563,0.0004592859,0.0002009834,0.00003452145,0.0001294086,0.9953589,0.00007438962,0.001351723],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.0605041,"threshold_uncertainty_score":0.2024064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326063729843533,"score_gpt":0.3684963149359322,"score_spread":0.3358899419515788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}