{"id":"W4232555203","doi":"10.21203/rs.2.13361/v4","title":"A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: Protocol for the immunosuppressant regimens for Living FEtuses (ILIFE) Trial","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cardiovascular Issues in Pregnancy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"National Key Research and Development Program of China","keywords":"Medicine; Undifferentiated connective tissue disease; Hydroxychloroquine; Pregnancy; Live birth; Prednisone; Randomized controlled trial; Adverse effect; Internal medicine; Connective tissue disease; Disease; Autoimmune disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005078634,0.0009406005,0.006389075,0.0005968108,0.0002702586,0.0003637007,0.001180673,0.0004254209,0.00007225176],"category_scores_gemma":[0.01821704,0.000577518,0.0008059918,0.0005715627,0.0006074203,0.0001621764,0.002670872,0.001154767,0.000001954867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007508897,"about_ca_system_score_gemma":0.001402654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003174182,"about_ca_topic_score_gemma":0.0001566885,"domain_scores_codex":[0.9902312,0.002701959,0.002058666,0.001866763,0.001853286,0.001288172],"domain_scores_gemma":[0.9822785,0.01265169,0.0008302793,0.002064862,0.001591949,0.0005826936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9633272,0.008664461,0.00004376641,0.01241266,0.004973623,0.00008679873,0.005596649,0.00003904303,0.0002357496,0.00006149905,0.0001660352,0.00439257],"study_design_scores_gemma":[0.9189041,0.02435904,0.0001276229,0.04878884,0.001754707,0.000008654247,0.0006156315,0.003661248,0.0005626397,0.0005544046,0.000143332,0.0005197446],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.119802,0.004062731,0.002442895,0.0007336013,0.0003744923,0.8716048,0.0008460765,0.00008197014,0.00005140049],"genre_scores_gemma":[0.3495657,0.0004354864,0.0004615464,0.00001197455,0.0003327295,0.6488258,0.0001041384,0.0001440728,0.0001185784],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2297637,"threshold_uncertainty_score":0.9996676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07410943842127271,"score_gpt":0.426405498588016,"score_spread":0.3522960601667433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}