{"id":"W4232578896","doi":"10.1002/ange.201400870","title":"Design of Monodisperse and Well‐Defined Polypeptide‐Based Polyvalent Inhibitors of Anthrax Toxin","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Anthrax toxin; Valency; Rational design; Chemistry; Peptide; Linker; Small molecule; Dendrimer; Ligand (biochemistry); Receptor; Biochemistry; Combinatorial chemistry; Nanotechnology; Materials science; Fusion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003892163,0.0004640854,0.0003858691,0.0002590874,0.0001694841,0.000550181,0.0004535578,0.000360845,0.0006779191],"category_scores_gemma":[0.0003201505,0.0002887066,0.0001736451,0.0001986606,0.0003157314,0.000325282,0.000234965,0.0006515582,0.0003806398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001005782,"about_ca_system_score_gemma":0.0003798105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004153631,"about_ca_topic_score_gemma":0.0008519767,"domain_scores_codex":[0.9997528,0.00004057829,0.00002866509,0.00005903476,0.00007555638,0.00004327742],"domain_scores_gemma":[0.9997626,0.00004893702,0.00008007113,0.00001694205,0.00004192984,0.00004952766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007861476,0.00006254896,0.00006195805,0.00005508819,0.000007183891,0.00003115898,0.00001842403,0.001560315,0.9955075,0.0006603277,0.00007062449,0.001886287],"study_design_scores_gemma":[0.0000403402,0.0002384567,0.0001265441,0.000005090963,0.0000111308,0.00003383061,0.000007829356,0.0049214,0.9921565,0.00005021568,0.002400927,0.000007746706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9257175,0.003002221,0.06478961,0.0001927985,0.00009533828,0.0004188952,0.0004390704,0.0002464674,0.005098047],"genre_scores_gemma":[0.9566126,0.001605911,0.03578124,0.0001369748,0.00002131425,0.0004501429,0.0004388293,0.00008214694,0.004870871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005782,"threshold_uncertainty_score":0.007297516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549450438939115,"score_gpt":0.2454459284727293,"score_spread":0.2299514240833381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}