{"id":"W4232629971","doi":"10.26434/chemrxiv.7119887","title":"Catalytic Enantioselective Benzylation Directly from Aryl Acetic Acids","year":2018,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Enantioselective synthesis; Decarboxylation; Electrophile; Chemistry; Nucleophile; Carbanion; Aryl; Allylic rearrangement; Combinatorial chemistry; Catalysis; Reactive intermediate; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002028369,0.0005552525,0.0007504481,0.0001889402,0.0001451112,0.0001380799,0.0007431234,0.0008365636,0.001330864],"category_scores_gemma":[0.0005302996,0.0005460665,0.0004659474,0.0003954506,0.0001552076,0.00009105825,0.0006278421,0.000655051,0.0005707584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003770614,"about_ca_system_score_gemma":0.0001917705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004854015,"about_ca_topic_score_gemma":0.00002665893,"domain_scores_codex":[0.9973221,0.00001848752,0.0005297013,0.001200367,0.0004839941,0.0004453113],"domain_scores_gemma":[0.9973742,0.000313888,0.0004967073,0.001423886,0.000221911,0.0001694597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003680689,0.001698133,0.07604423,0.002115469,0.008453649,0.0001048107,0.005074721,0.0001027373,0.4706591,0.000126749,0.02833698,0.4069153],"study_design_scores_gemma":[0.0002588993,0.000007527969,0.003818729,0.0002551684,0.0006353254,0.000001995465,0.00009856473,0.0007448773,0.9894159,0.001908828,0.002183366,0.0006708589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9000631,0.002220635,0.0006001007,0.0001249478,0.0004472412,0.0001532103,0.000107778,0.0003374965,0.09594548],"genre_scores_gemma":[0.994237,0.0001708421,0.0004113293,0.00003153421,0.001466256,0.0001136641,0.001497826,0.00009823611,0.001973304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5187567,"threshold_uncertainty_score":0.9996991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518028255176707,"score_gpt":0.2367690330374516,"score_spread":0.2215887504856845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}