{"id":"W4232737588","doi":"10.1073/pnas.1211284110","title":"Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Fonds de recherche du Québec; Université Laval; Fonds de Recherche du Québec - Santé","funders":"National Eye Institute; National Institutes of Health; Macula Vision Research Foundation; Research to Prevent Blindness; Glaucoma Research Foundation; American Health Assistance Foundation","keywords":"Neuroprotection; Kinome; Retinal ganglion cell; Programmed cell death; Neuroscience; Biology; Optic nerve; Optic neuropathy; Cell biology; Conditional gene knockout; Kinase; Phenotype; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000782932,0.0001184416,0.0002224379,0.0002627503,0.0001540823,0.00001695209,0.0002788801,0.00009334938,0.000240605],"category_scores_gemma":[0.0004920512,0.00007581313,0.0001310776,0.0004871351,0.0007443585,0.00029614,0.0001169083,0.0001937013,0.00001241927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002435802,"about_ca_system_score_gemma":0.00007185972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005034322,"about_ca_topic_score_gemma":7.60242e-8,"domain_scores_codex":[0.9977161,0.000007452426,0.0004219415,0.0002405437,0.001434359,0.0001795709],"domain_scores_gemma":[0.9988302,0.00009348022,0.0004506934,0.00001171287,0.0005427645,0.0000711664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001022519,0.00009820607,0.1198284,0.0001943352,0.00002383696,4.837148e-8,0.0002427527,0.00001267581,0.8703321,0.005719536,0.003348696,0.00009719173],"study_design_scores_gemma":[0.0004886242,0.0001659759,0.6540962,0.0001719419,0.00004633336,0.00003811594,0.0008025652,0.0004376227,0.3360355,0.007573786,0.00007067632,0.00007258716],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871314,0.0003349102,0.000001822871,0.004548377,0.00003759106,0.0002693711,0.000006148862,0.00001036512,0.007660025],"genre_scores_gemma":[0.9973655,0.00004313387,0.001382844,0.0002394936,0.0001364199,0.00001223052,8.831132e-7,0.000006617573,0.0008128631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5342965,"threshold_uncertainty_score":0.309157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867420410934909,"score_gpt":0.272136589656865,"score_spread":0.2434623855475159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}