{"id":"W4232737588","doi":"10.1073/pnas.1211284110","title":"Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Fonds de recherche du Québec; Université Laval; Fonds de Recherche du Québec - Santé","funders":"National Eye Institute; National Institutes of Health; Macula Vision Research Foundation; Research to Prevent Blindness; Glaucoma Research Foundation; American Health Assistance Foundation","keywords":"Neuroprotection; Kinome; Retinal ganglion cell; Programmed cell death; Neuroscience; Biology; Optic nerve; Optic neuropathy; Cell biology; Conditional gene knockout; Kinase; Phenotype; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580218,0.0003580171,0.0002712412,0.0003548172,0.0001823167,0.0002750986,0.0002199142,0.0002659165,0.001351796],"category_scores_gemma":[0.0001499559,0.0001129053,0.000228962,0.0001786511,0.0002047244,0.00008142267,0.0001739757,0.0002557613,0.0004322196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357219,"about_ca_system_score_gemma":0.0002688171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005689318,"about_ca_topic_score_gemma":0.001247077,"domain_scores_codex":[0.9998739,0.00001622174,0.00001078884,0.00002433199,0.00004966709,0.00002500848],"domain_scores_gemma":[0.9999125,0.00002356679,0.00002595608,0.0000070064,0.000009297742,0.00002157757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007040191,0.00002314164,0.0003557891,0.00002138537,0.000004380566,0.00008107461,0.000003696385,0.00008188226,0.9982226,0.0000521472,0.0000272496,0.001056096],"study_design_scores_gemma":[0.00002370442,0.0003554467,0.006366572,0.000003358067,0.00003042089,0.0005175232,0.00001723417,0.0008924325,0.9904294,0.00005240872,0.001306827,0.000004613394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990302,0.001246925,0.004549117,0.0001685222,0.00002096432,0.00005709442,0.001317262,0.0001663443,0.002171573],"genre_scores_gemma":[0.9924462,0.0006691327,0.003673697,0.00008874747,0.00000625696,0.00002278422,0.001693551,0.00001814047,0.001381541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351796,"threshold_uncertainty_score":0.004522204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867420410934909,"score_gpt":0.272136589656865,"score_spread":0.2434623855475159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}