{"id":"W4232768691","doi":"10.1139/cjpp-78-2-143","title":"Orexigenic effect of the melanocortin MC<sub>4</sub> receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y<sub>1</sub> receptor selective antagonists","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Neuropeptide Y receptor; Endocrinology; Internal medicine; Receptor; Chemistry; Orexigenic; Melanocortin receptor; Melanocortin 4 receptor; Antagonist; Melanocortin; Biology; Molecular biology; Neuropeptide; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366624,0.000408885,0.0008131415,0.0001921863,0.0002344689,0.0003262071,0.0003506645,0.0003056539,0.005249981],"category_scores_gemma":[0.000231382,0.0003970533,0.0002995229,0.0001466879,0.0004640978,0.0003056489,0.0002165228,0.001297982,0.001138172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004544082,"about_ca_system_score_gemma":0.0009293659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002439385,"about_ca_topic_score_gemma":0.008208415,"domain_scores_codex":[0.999855,0.00002152745,0.00001025232,0.00001223168,0.00002775099,0.00007318521],"domain_scores_gemma":[0.9999033,0.00002173048,0.00001678594,0.000009999111,0.00000774106,0.00004037501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002351948,0.0001385745,0.000208791,0.00006282318,0.00002956145,0.0001205673,0.00003483961,0.0001337675,0.9932213,0.0004289433,0.0003056027,0.002963227],"study_design_scores_gemma":[0.001078165,0.004426209,0.01453252,0.00002530671,0.00008814667,0.0009474022,0.0001306984,0.001526118,0.9688224,0.0002902275,0.008096052,0.00003669597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924912,0.001201851,0.0006030912,0.0002224891,0.00003896047,0.00003107521,0.0003483896,0.0000616855,0.005001221],"genre_scores_gemma":[0.9851297,0.001963222,0.001791042,0.0001968953,0.00004258691,0.00005851033,0.001734952,0.00004828873,0.009034779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005249981,"threshold_uncertainty_score":0.01756293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00776452071895012,"score_gpt":0.2401843762796828,"score_spread":0.2324198555607326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}