{"id":"W4232774961","doi":"10.1182/blood-2019-124457","title":"A Randomized Phase II, Open Label, Study of Daratumumab, Weekly Low-Dose Oral Dexamethasone and Cyclophosphamide with or without Pomalidomide in Patients with Relapsed and Refractory Multiple Myeloma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Calgary; Thunder Bay Regional Health Sciences Centre; Ottawa Hospital; CancerCare Manitoba; Queen Elizabeth II Health Sciences Centre; University of New Brunswick; Dalhousie University; University of Ottawa; McGill University Health Centre; Juravinski Cancer Centre; Saint John Regional Hospital; BC Cancer Agency","funders":"","keywords":"Pomalidomide; Daratumumab; Medicine; Dexamethasone; Lenalidomide; Internal medicine; Cyclophosphamide; Oncology; Multiple myeloma; Regimen; Pharmacology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004634748,0.004223383,0.004685915,0.001029307,0.0009846489,0.002192095,0.001897503,0.003151807,0.01063244],"category_scores_gemma":[0.002978837,0.00217089,0.002725111,0.0008422863,0.004259818,0.002613823,0.0008803869,0.005477799,0.0023431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001414099,"about_ca_system_score_gemma":0.003646813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251071,"about_ca_topic_score_gemma":0.002315806,"domain_scores_codex":[0.998238,0.0009117021,0.00009491519,0.0003316102,0.0001177686,0.0003059765],"domain_scores_gemma":[0.9973086,0.0006586607,0.0004174032,0.0002336499,0.0001340771,0.001247621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9525827,0.03536208,0.0007351218,0.0002538641,0.000298514,0.00006135712,0.0000815188,0.000317556,0.003127298,0.000122938,0.0005376407,0.006519372],"study_design_scores_gemma":[0.8998888,0.09865019,0.000554984,0.000006966302,0.00009242094,0.00002045972,0.00001422514,0.000204688,0.0002030279,0.00007687992,0.0002760179,0.00001119417],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797855,0.00142077,0.0008369298,0.0011344,0.0009534646,0.01277575,0.001087265,0.0001462647,0.001859732],"genre_scores_gemma":[0.9661118,0.002020312,0.00352957,0.002671018,0.001505485,0.01641851,0.001736029,0.00004637789,0.005960934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063244,"threshold_uncertainty_score":0.03556901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497506063718746,"score_gpt":0.3162439529956668,"score_spread":0.2912688923584793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}