{"id":"W4232775912","doi":"10.1200/jco.2002.20.6.1519","title":"Randomized, Open-Label, Phase III Study of a 28-Day Oral Regimen of Eniluracil Plus Fluorouracil Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Therapy in Patients With Metastatic/Advanced Colorectal Cancer","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Cancer Centre","funders":"","keywords":"Medicine; Fluorouracil; Tolerability; Gastroenterology; Internal medicine; Regimen; Hazard ratio; Mucositis; Colorectal cancer; Clinical endpoint; Phases of clinical research; Surgery; Randomized controlled trial; Confidence interval; Chemotherapy; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002636155,0.001894047,0.003284567,0.0004990898,0.0005541444,0.001182896,0.00133688,0.001607297,0.005291135],"category_scores_gemma":[0.002503546,0.0008919065,0.001475545,0.0004832579,0.001996839,0.00105137,0.0004298784,0.003245189,0.0008961307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001203639,"about_ca_system_score_gemma":0.00257751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001699385,"about_ca_topic_score_gemma":0.004628338,"domain_scores_codex":[0.998965,0.0006537407,0.00005064168,0.0001327003,0.00006968687,0.0001282388],"domain_scores_gemma":[0.99793,0.0005657126,0.0004286913,0.0001484443,0.00012319,0.0008037529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9646302,0.0212659,0.0007917479,0.000242211,0.0004503517,0.00003201064,0.00005070403,0.0003589125,0.003234823,0.00007786568,0.0005273917,0.008337917],"study_design_scores_gemma":[0.8815991,0.1158466,0.00116248,0.00001026577,0.0001467852,0.00002329151,0.00001718788,0.0004468529,0.0003641361,0.00006299151,0.0003108133,0.000009530807],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99009,0.001208995,0.0006681657,0.0004410501,0.0005111916,0.005274766,0.0007816085,0.00009419595,0.0009300275],"genre_scores_gemma":[0.9864594,0.001013763,0.002405489,0.001048238,0.0005407765,0.005552465,0.0009843415,0.00002465722,0.001970923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005291135,"threshold_uncertainty_score":0.01770061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1616814047113093,"score_gpt":0.4588486052744729,"score_spread":0.2971672005631635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}