{"id":"W4232945305","doi":"10.32920/ryerson.14665104.v1","title":"Progress Toward the Synthesis of Labeled Derivatives of the Cystic Fibrosis Drug Ivacaftor","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Ivacaftor; Cystic fibrosis; Potentiator; Cystic fibrosis transmembrane conductance regulator; Mutation; Medicine; Pharmacology; Bioinformatics; Chemistry; Cancer research; Biology; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396865,0.000379516,0.0002659426,0.0002792791,0.0001851331,0.0002690797,0.0003538665,0.0004285065,0.00339105],"category_scores_gemma":[0.0003212815,0.0001967174,0.0004156405,0.0002700702,0.0001866302,0.000508525,0.0003087396,0.00105949,0.00164716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421074,"about_ca_system_score_gemma":0.0005453717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008996946,"about_ca_topic_score_gemma":0.001168872,"domain_scores_codex":[0.9997897,0.00004273162,0.00001927381,0.00004214418,0.00006156441,0.00004460292],"domain_scores_gemma":[0.9999155,0.00001419624,0.00002092729,0.00001216354,0.00002113322,0.00001610161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004056542,0.0003012574,0.0003869834,0.00193596,0.00008641235,0.0006935946,0.0003332267,0.0022836,0.8969198,0.01390963,0.004254462,0.07848946],"study_design_scores_gemma":[0.00008906815,0.001519357,0.0008224659,0.0001497302,0.00008642313,0.0006335046,0.00007544201,0.001732953,0.8158644,0.0009305345,0.1780292,0.00006686743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5886653,0.1144373,0.1860869,0.003482109,0.00159595,0.001456236,0.005278226,0.00160682,0.09739109],"genre_scores_gemma":[0.8729182,0.04627774,0.05157526,0.0008868624,0.0001722727,0.0004234597,0.00248457,0.0002554072,0.02500619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00339105,"threshold_uncertainty_score":0.01134419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190983064475841,"score_gpt":0.3128155947225374,"score_spread":0.290905764077779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}