{"id":"W4232977820","doi":"10.22215/etd/2021-14376","title":"Mass Spectrometry-based Anaylsis to Investigate the Pharmacokinetics and Proteomic Properties of a Viral Sensitizer","year":2021,"lang":"en","type":"dissertation","venue":"","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Pharmacokinetics; Oncolytic virus; Chemistry; Mass spectrometry; Pharmacology; Computational biology; Cancer research; Medicine; Biology; Chromatography; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004176131,0.0006496787,0.0004416014,0.001062247,0.0003836096,0.0004637334,0.0003018285,0.0007215078,0.002331302],"category_scores_gemma":[0.0004888466,0.0002688653,0.000512851,0.000576415,0.0002665203,0.000499008,0.0003113463,0.0009544051,0.0009689227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412881,"about_ca_system_score_gemma":0.000414714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016273,"about_ca_topic_score_gemma":0.001343745,"domain_scores_codex":[0.9997411,0.00003152218,0.00001580282,0.00007763805,0.0001050256,0.00002880987],"domain_scores_gemma":[0.9997039,0.00008046431,0.00007630606,0.00002460125,0.00008731071,0.00002735239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001298552,0.00004931212,0.0008501321,0.00007504908,0.00002783583,0.00006423477,0.00002768933,0.00008584748,0.9945463,0.0001167541,0.0001148679,0.003912111],"study_design_scores_gemma":[0.00001281927,0.0004419389,0.007197478,0.00001005319,0.00004495327,0.0005468285,0.00007293477,0.004969516,0.9822698,0.0001867144,0.004223541,0.00002344273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8623089,0.008236361,0.1159808,0.000565095,0.0002988344,0.0005087047,0.004430428,0.001621145,0.006049657],"genre_scores_gemma":[0.8705012,0.006851955,0.1033603,0.00100321,0.0001009325,0.0006299361,0.002797833,0.0002654479,0.01448919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331302,"threshold_uncertainty_score":0.007799029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754556754733617,"score_gpt":0.2859626612010234,"score_spread":0.2684170936536872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}