{"id":"W4233078754","doi":"10.1111/j.1574-695x.2010.00645.x","title":"Autoactivation of the AggR regulator of enteroaggregative<i>Escherichia coli in vitro</i>and<i>in vivo</i>","year":2010,"lang":"en","type":"article","venue":"FEMS Immunology & Medical Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Enteroaggregative Escherichia coli; Biology; Regulator; DNA footprinting; Primer extension; Fimbria; Luciferase; Transcriptional regulation; Virulence; Plasmid; Response regulator; Regulation of gene expression; Microbiology; Molecular biology; Escherichia coli; Genetics; Promoter; Gene; Gene expression; Enterobacteriaceae; Nucleotide; Transfection; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785302,0.0003306791,0.000154213,0.0001266129,0.00006743798,0.00026918,0.0001019719,0.0001608612,0.000792165],"category_scores_gemma":[0.0001582063,0.00009599104,0.0001876235,0.00007800511,0.0001658717,0.00007414359,0.0001922801,0.0003766989,0.0005679923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580155,"about_ca_system_score_gemma":0.0001261929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003683624,"about_ca_topic_score_gemma":0.0004796451,"domain_scores_codex":[0.999742,0.00008479117,0.0000170713,0.00004826254,0.00005914683,0.00004879783],"domain_scores_gemma":[0.9998672,0.00003447042,0.0000361127,0.00002442196,0.00001745723,0.0000203865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000208956,0.000008410969,0.0000790526,0.00000749639,8.362758e-7,0.0000134415,0.00000397117,0.00001259762,0.9995646,0.00002247788,0.000009537614,0.0002566924],"study_design_scores_gemma":[0.000002710799,0.00008488755,0.004164503,0.000003425117,0.000004169932,0.0001339654,0.00001853769,0.0004327481,0.9942608,0.00001750344,0.0008743237,0.000002515068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928839,0.0007998671,0.004068727,0.00008068355,0.00002472978,0.00001609443,0.0002893682,0.00008289653,0.001753744],"genre_scores_gemma":[0.9920061,0.0004064897,0.003349925,0.0001029425,0.00001119643,0.00002301459,0.001066025,0.00004934211,0.002984863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000792165,"threshold_uncertainty_score":0.002650082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004699231563035432,"score_gpt":0.235608109260456,"score_spread":0.2309088776974206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}