{"id":"W4233078754","doi":"10.1111/j.1574-695x.2010.00645.x","title":"Autoactivation of the AggR regulator of enteroaggregative<i>Escherichia coli in vitro</i>and<i>in vivo</i>","year":2010,"lang":"en","type":"article","venue":"FEMS Immunology & Medical Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Enteroaggregative Escherichia coli; Biology; Regulator; DNA footprinting; Primer extension; Fimbria; Luciferase; Transcriptional regulation; Virulence; Plasmid; Response regulator; Regulation of gene expression; Microbiology; Molecular biology; Escherichia coli; Genetics; Promoter; Gene; Gene expression; Enterobacteriaceae; Nucleotide; Transfection; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005623029,0.0001689431,0.0004020602,0.00009236114,0.00003964853,0.000002117334,0.0004628544,0.0005785609,0.00004968486],"category_scores_gemma":[0.001464178,0.0001265831,0.0000777218,0.0002377874,0.001914695,0.000004315281,0.0005674415,0.0006521596,9.657507e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001828849,"about_ca_system_score_gemma":0.0002369447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384229,"about_ca_topic_score_gemma":0.0008280731,"domain_scores_codex":[0.9983595,0.0003800489,0.000472509,0.0003451919,0.00008753203,0.0003551997],"domain_scores_gemma":[0.999111,0.0001375055,0.0002329735,0.0003857183,0.00008992362,0.00004285934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003817129,0.0001556509,0.01529993,0.00002178699,0.00008311989,0.00000190507,0.0001591765,5.0867e-7,0.9829519,0.0000786083,0.0001054882,0.000760172],"study_design_scores_gemma":[0.001243306,0.0001734081,0.07104184,0.00004426918,0.00000600375,0.00002468836,0.00008604878,0.00001640009,0.9213076,0.00006912171,0.005888136,0.00009912668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969453,0.001135514,0.0000157649,0.001064556,0.0003758518,0.0002843167,0.00002315139,0.000004920375,0.0001506887],"genre_scores_gemma":[0.9988853,0.0004000525,0.0002397377,0.0002323121,0.00004448657,0.00004333512,0.0000175724,0.00001339846,0.0001238006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0616443,"threshold_uncertainty_score":0.7054774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004699231563035432,"score_gpt":0.235608109260456,"score_spread":0.2309088776974206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}