{"id":"W4233109317","doi":"10.1002/ange.202014162","title":"Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Alberta","keywords":"Ribonucleoprotein; CRISPR; Cas9; HeLa; Corona (planetary geology); Chemistry; HEK 293 cells; Cell biology; Gene delivery; RNA; Computational biology; Biophysics; Nanotechnology; Cell; Gene; Biology; Genetic enhancement; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488809,0.0001950977,0.0002173746,0.0001325726,0.0001184178,0.0002723218,0.0002147075,0.0003455359,0.0005554183],"category_scores_gemma":[0.0001869367,0.0001541682,0.0002119868,0.00009874022,0.000193082,0.0001226946,0.0002704224,0.0003383125,0.0002227608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003247924,"about_ca_system_score_gemma":0.0002421945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000490713,"about_ca_topic_score_gemma":0.0007071883,"domain_scores_codex":[0.9997322,0.00004446942,0.00002460232,0.00006187995,0.0000952115,0.0000416957],"domain_scores_gemma":[0.9998658,0.00002362816,0.00004106611,0.00002052263,0.00002386217,0.00002508794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008342665,0.0000055977,0.00002536093,0.00001212791,0.00000184011,0.00001752127,0.000006894224,0.0001319957,0.9989937,0.0001202696,0.00003753721,0.0006388749],"study_design_scores_gemma":[0.000003450589,0.00002064728,0.000199636,0.000001287778,0.000001558075,0.00003770054,0.000002807129,0.002132822,0.9964317,0.00002825129,0.001136568,0.000003535579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9239576,0.0008216512,0.07031211,0.0001839962,0.00009413851,0.0001351443,0.0003473288,0.0006371805,0.003510757],"genre_scores_gemma":[0.9743112,0.000264215,0.02257309,0.00006827783,0.000007617432,0.00005968944,0.0002664094,0.00005986137,0.002389601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005554183,"threshold_uncertainty_score":0.00235647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615804975083495,"score_gpt":0.2323146784656141,"score_spread":0.2161566287147791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}