{"id":"W4233168389","doi":"10.12688/f1000research.18963.1","title":"Human aldose reductase unfolds through an intermediate.","year":2019,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Aldose reductase; Equilibrium unfolding; Polyol pathway; Sorbitol; Chemistry; Cooperativity; Native state; Aldose reductase inhibitor; Circular dichroism; Biochemistry; Biophysics; Thermostability; Crystallography; Enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473181,0.0002965361,0.0001507378,0.0001236407,0.0002162092,0.0001738968,0.000294249,0.0003630129,0.002061063],"category_scores_gemma":[0.0003487305,0.0001290941,0.0003150267,0.0001770798,0.0001783847,0.000274853,0.00015762,0.0006158453,0.0007779818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315344,"about_ca_system_score_gemma":0.0001830605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030436,"about_ca_topic_score_gemma":0.0006970878,"domain_scores_codex":[0.9998493,0.00002172847,0.000008324257,0.0000533293,0.00004022928,0.00002695807],"domain_scores_gemma":[0.9998866,0.00002260354,0.00003762537,0.00000804512,0.00002761142,0.00001734258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002139381,0.00008573867,0.001152556,0.00011242,0.00002864746,0.0003692806,0.00009761045,0.0002076013,0.9933804,0.000376132,0.0007427724,0.003232844],"study_design_scores_gemma":[0.0000095933,0.0002740666,0.00661255,0.0000139672,0.00002246049,0.0007995255,0.0000458252,0.001451308,0.9853547,0.0002300259,0.005170738,0.00001521342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781503,0.003178755,0.01184936,0.0006312922,0.0001310067,0.00006444678,0.001242478,0.00036622,0.004386255],"genre_scores_gemma":[0.9879904,0.000631015,0.004219224,0.0002792814,0.00001681364,0.00003637321,0.002086043,0.00004578799,0.004694993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061063,"threshold_uncertainty_score":0.006894946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04733544872083262,"score_gpt":0.3840972983475968,"score_spread":0.3367618496267641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}