{"id":"W4233196845","doi":"10.32920/ryerson.14646279.v1","title":"Ultrasound-Microbubble Combined Treatment with Vinca Alkaloids in Prostate Cancer Cells","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Plant-based Medicinal Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Vinca; Vinblastine; Vinca alkaloid; Vinorelbine; Microbubbles; Cytotoxicity; Pharmacology; Alkaloid; Drug; Chemotherapy; Docetaxel; Viability assay; Prostate; Paclitaxel; Chemistry; Cancer research; Cancer; Medicine; Apoptosis; Ultrasound; Internal medicine; Biochemistry; Stereochemistry; In vitro; Cisplatin; Vincristine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000836615,0.0002058144,0.0003282777,0.0001914309,0.0001334486,0.000217648,0.0001636495,0.0003085454,0.001997787],"category_scores_gemma":[0.00005623111,0.0001121454,0.0002098795,0.0002281945,0.0001334852,0.0001302535,0.0001484188,0.0003293391,0.000457067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206795,"about_ca_system_score_gemma":0.0001655645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002726516,"about_ca_topic_score_gemma":0.002982789,"domain_scores_codex":[0.9999068,0.00001473885,0.000004486337,0.00001875711,0.00002892281,0.00002619113],"domain_scores_gemma":[0.9999725,0.000009996552,0.000003632744,0.000003591815,0.000004760666,0.00000555782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002082334,0.00005498063,0.0001485174,0.00009816315,0.000009837547,0.0001115165,0.00004557324,0.0002258772,0.9937686,0.00008207793,0.0002052617,0.005041378],"study_design_scores_gemma":[0.00001969058,0.0005336039,0.003084265,0.000005027565,0.00001506048,0.0001400624,0.00002395467,0.001165887,0.9922681,0.00001526953,0.002725183,0.0000039981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849592,0.005364074,0.001787964,0.0001651271,0.00007797004,0.00004567952,0.0003810075,0.0001115285,0.007107579],"genre_scores_gemma":[0.9870173,0.001779327,0.00189439,0.00005955657,0.00002694163,0.00004779517,0.0003505277,0.00002172569,0.008802462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002726516,"threshold_uncertainty_score":0.00668329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0927540080646174,"score_gpt":0.4353887920547657,"score_spread":0.3426347839901482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}