{"id":"W4233298496","doi":"10.1111/j.1745-7270.2008.00448.x","title":"Simultaneous knockdown of p18<sup>INK4C</sup>, p27<sup>Kip1</sup>and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells<i>in vitro</i>","year":2008,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Gene knockdown; RNA interference; Cell biology; Haematopoiesis; Stem cell; Biology; Bone marrow; Small hairpin RNA; Cell cycle; Cell division; Cell culture; Cancer research; Cell; Immunology; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006475645,0.0004836432,0.0007834393,0.0002025646,0.00009570487,0.00002027879,0.0009165928,0.0003490109,0.00001218852],"category_scores_gemma":[0.0002317065,0.0003897155,0.000265199,0.0005284398,0.000731887,0.00002344743,0.0004628303,0.0005338292,0.000005527464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000285058,"about_ca_system_score_gemma":0.0001697265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001267981,"about_ca_topic_score_gemma":0.00005160025,"domain_scores_codex":[0.9962294,0.0005294604,0.00127054,0.0008685525,0.0005099525,0.0005921446],"domain_scores_gemma":[0.9974023,0.0004282436,0.0005947257,0.001210193,0.0002358586,0.0001287108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006514878,0.0008540732,0.00005114061,0.0001690893,0.00007700649,0.0000490769,0.002214106,0.0005305142,0.9873955,0.000001892121,0.0001456843,0.001997053],"study_design_scores_gemma":[0.002420271,0.003316841,0.0003690568,0.0002048674,0.00003152225,0.00003177682,0.0002029494,0.001808117,0.9911633,0.00001897564,0.00006040236,0.0003719395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977894,0.0004670812,0.0000192206,0.0003576766,0.00003047521,0.0006288592,0.0003773491,0.00001267146,0.0003172791],"genre_scores_gemma":[0.9961806,0.002501233,0.0005482226,0.0002147026,0.0001075208,0.00002527758,0.0002745504,0.00005709338,0.00009083561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004094607,"threshold_uncertainty_score":0.9998555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523259603683097,"score_gpt":0.2703513508924096,"score_spread":0.2551187548555786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}