{"id":"W4233298496","doi":"10.1111/j.1745-7270.2008.00448.x","title":"Simultaneous knockdown of p18<sup>INK4C</sup>, p27<sup>Kip1</sup>and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells<i>in vitro</i>","year":2008,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Gene knockdown; RNA interference; Cell biology; Haematopoiesis; Stem cell; Biology; Bone marrow; Small hairpin RNA; Cell cycle; Cell division; Cell culture; Cancer research; Cell; Immunology; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352057,0.0004829158,0.0002974053,0.0002783742,0.0001837874,0.0003562998,0.0003099402,0.000253472,0.001527507],"category_scores_gemma":[0.00008226658,0.0001747417,0.0003746435,0.0002371394,0.0003443072,0.0002398734,0.0002406734,0.0007784861,0.000594372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254501,"about_ca_system_score_gemma":0.0002793995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008111205,"about_ca_topic_score_gemma":0.001230854,"domain_scores_codex":[0.9997466,0.00001836308,0.00004249744,0.0000730131,0.00006903084,0.00005039906],"domain_scores_gemma":[0.9998547,0.00002591055,0.00004656278,0.0000190322,0.000009552455,0.00004416665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007615815,0.00002111909,0.0001585393,0.00003968388,0.000007595841,0.0000557616,0.00001179653,0.00007070747,0.9983077,0.0001875906,0.00007788021,0.0009854219],"study_design_scores_gemma":[0.000007024847,0.00006247363,0.001642157,0.000002531452,0.00001237794,0.0001043441,0.0000101568,0.0007912731,0.9952291,0.00002296066,0.002112818,0.000002784539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981609,0.00163288,0.009763638,0.0001496483,0.0001070985,0.00005990123,0.002378173,0.0004483478,0.003851411],"genre_scores_gemma":[0.9807575,0.0009424788,0.006754881,0.00008652049,0.00001803167,0.0001278802,0.00292172,0.0001222623,0.00826875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527507,"threshold_uncertainty_score":0.005110085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523259603683097,"score_gpt":0.2703513508924096,"score_spread":0.2551187548555786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}